子宫内膜间质肉瘤磁共振扩散加权成像ADC值与恶性生物学特征的相关性研究

Correlation between magnetic resonance diffusion-weighted imaging ADC value of endometrial stromal sarcoma and the malignant biological features

目的:研究子宫内膜间质肉瘤磁共振扩散加权成像ADC值与恶性生物学特征的相关性。方法:选择在本院接受手术切除的34例子宫内膜间质肉瘤患者作为研究的恶性组,接受手术切除的58例子宫肌瘤患者作为对照组。术前进行磁共振扩散加权成像并测定表观扩散系数(ADC值);术后收集病灶组织并测定增殖基因及雌孕激素受体的表达量。结果:恶性组子宫内膜间质肉瘤的ADC值显著低于对照组;恶性组子宫内膜间质肉瘤病灶中CyclinD1、Rb、Sp1、Survivin、ERα、ERβ、PRA、PRB的蛋白表达量显著高于对照组,SULT1E1的蛋白表达量显著低于对照组;低ADC值亚组子宫内膜间质肉瘤病灶中CyclinD1、Rb、Sp1、Survivin、ERα、ERβ、PRA、PRB的蛋白表达量显著高于高ADC值亚组,SULT1E1的蛋白表达量显著低于高ADC值亚组。结论:磁共振扩散加权成像ADC值能够用于评估子宫内膜间质肉瘤的恶性生物学行为。

Objective： To study the correlation between magnetic resonance diffusion-weighted imaging ADC value of endometrial stromal sarcoma and the malignant biological features. Methods： A total of 34 patients with endometrial stromal sarcoma who received surgical resection in Hubei Provincial Hospital of Integrated Chinese Western Medicine between May 2014 and August 2016 were selected as the malignant group of the research, and 58 patients with uterine fibroids who received surgical resection between August 2015 and October 2016 were selected as the control group of the research. Magnetic resonance diffusion-weighted imaging was done before operation to measure apparent diffusion coefficient （ADC value）. The lesions were collected after operation to determine the expression of proliferation genes as well as estrogen and progestogen receptors. Results： Endometrial stromal sarcoma ADC value of malignant group was significantly lower than uterine fibroid ADC value of control group; CyclinD1, Rb, Spl, Survivin, ERα, ERβ, PRA and PRB protein expression in endometrial stromal sarcoma lesions of malignant group were significantly higher than those of control group while SULT1E1 protein expression was significantly lower than that of control group; CyclinD1, Rb, Spl, Survivin, ERα, ERβ, PRA and PRB protein expression in endometrial stromal sarcoma lesions of subgroup with low ADC value were significantly higher than those of subgroup with high ADC value while SULT1E1 protein expression was significantly lower than that of subgroup with high ADC value. Conclusions： Magnetic resonance diffusion weighted imaging ADC values can be used to evaluate the malignant biological behavior of endom- etrial stromaI sarcoma.