阿司匹林预处理对多囊卵巢综合征行IVF-ET的疗效及其机制研究

Study on the Effect and Mechanism of Aspirin Pretreatment on IVF-ET in Patients with Polycystic Ovary Syndrome

目的:探讨阿司匹林预处理对多囊卵巢综合征行试管婴儿(invitro fertilization-embryo transfer,IVF-ET)的疗效及其机制。方法:选取2015年1月-2016年6月在珠海市妇幼保健院生殖中心因多囊卵巢综合征行试管婴儿治疗的患者119例,采用随机数字表法将患者分为研究组(62例)和对照组(57例)。研究组在IVF-ET治疗前给予阿司匹林预处理,对照组给予安慰剂治疗。观察比较两组患者的促性腺激素(Gn)使用时间、Gn使用剂量、获卵数、2PN受精率、优质胚胎数、启动日T淋巴细胞、肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)及IVF-ET结局。结果:研究组患者的Gn使用时间短于对照组,Gn使用剂量低于对照组,获卵数和优质胚胎数均高于对照组,差异均有统计学意义(P<0.05)。研究组患者的启动日T淋巴细胞、TNF-α和IL-6水平均低于对照组,差异均有统计学意义(P<0.05)。研究组患者的临床妊娠率和胚胎种植率均高于对照组,流产率低于对照组,但差异均无统计学意义(P>0.05)。结论:阿司匹林预处理对多囊卵巢综合征行IVF-ET有积极的临床意义。

Objective： To investigate the effect and mechanism of Aspirin pretreatment on invitro fertilization-embryo transfer （ IVF-ET ） in polyeystic ovary syndrome （ PCOS ） .Method： From January 2015 to June 2016, in the reproductive center of Maternal and Child Health Care Hospital of Zhuhai, 119 patients with polyeystic ovary syndrome were treated with IVF-ET and selected, they were divided into research group （ 62 cases ） and control group （ 57 cases ） according to the random number table method.The research group was given Aspirin before IVF-ET treatment, the control group was given placebo.The Gonadotropin （ Gn ） using time, Gn using dosage, amount of acquired oocytes, high-quality embryos, level of the serum T lymphocytes, TNF- α and IL-6 at the initiation day and clinical results of the two groups were observed and compared.Result： The Gn using time of the research group was shorter than that of the control group, and the dosage of Gn was lower than that of the control group, the amount of the acquired oocytes and high-quality embryos of the research group were all more than those of the control group, the differences were statistically significant （ P〈0.05 ） .The levels of T lymphocytes, TNF-α and IL-6 at the initiation day ofthe research group were lower than those of the control group, the differences were statistically significant （ P〈0.05 ） .The pregnancy rate and implantation rate of research group were higher than those in control group, the abortion rate was lower than that in control group, but the differences were not statistically significant （P〉0.05） .Conclusion： Aspirin pretreatment has positive clinical significance in the treatment of polycystic ovary syndrome with IVF-ET.