血、尿β_2微球蛋白在诊断糖尿病肾病患者早期肾损伤中的价值分析

The Value Study of Blood and Urine β2-microglobulin on the Diagnosis of Early Renal Injury in Patients with Diabetic Nephropathy

目的:探讨血、尿β_2微球蛋白在糖尿病患者早期肾损伤中的诊断价值。方法:选择2014年12月-2016年12月入住本院的糖尿病患者120例,根据临床是否并发糖尿病肾病症状分为研究组和对照组,各60例,研究组伴有早期糖尿病肾病,对照组未并发糖尿病肾病,且选择同期于该院健康体检者65例作为正常组。记录三组血肌酐(Serum creatinine,Scr)、尿素(Urea)与血、尿β_2微球蛋白水平以及上述各指标的阳性检出率。结果:研究组和对照组的Urea和Scr均明显高于正常组,差异均有统计学意义(P<0.05);研究组的Urea和Scr均高于对照组,差异均有统计学意义(P<0.05)。研究组血、尿β_2微球蛋白水平均明显高于对照组和正常组,差异均有统计学意义(P<0.05);对照组血、尿β_2微球蛋白水平均明显高于正常组,差异均有统计学意义(P<0.05)。研究组中有血β_2微球蛋白者52例(86.7%),有尿β_2微球蛋白者45例(75.0%),利用血β_2微球蛋白检出糖尿病肾病的比例比尿β_2微球蛋白检出率高,差异有统计学意义(P<0.05)。结论:血、尿β_2微球蛋白在诊断糖尿病肾病患者早期肾损伤中的价值较高,值得推广。

Objective： To evaluate the diagnostic value of blood and urine β2-microglobulin in early diabetie nephropathy.Method： A total of 120 patients with diabetes mellitus from December 2014 to December 2016 were selected and divided into the control group and the study group, according to the clinical symptoms of diabelie nephropathy, 60 cases in each group, the patients in the study group were early diabetic nephropathy, the paiients in the control group were not diabetic nephropathy, 65 normal persons of the same period were chosen as the normal group.The scores of Barthel index （ Urea, Scr ）, blood and urine β2-microglobulin of three groups were detected and compared.Result： The levels of Urea and Scr of the study group and the control group were significantly higher than those of the normal group （ P〈0.05 ）, the levels of Urea and Scr of the study group were higher than those of the control group, the differences were statistically significant, the differences were statistically significant （ P〈0.05 ）, the levels of blood and urine β2-microglobulin of lhe study group were significantly higher than those of the control group and the normal group, the differences were statistically significant （ P〈0.05 ） .the blood and urine β2-mieroglobulin levels of the control group were significantly higher than those of the normal group, the differences were statistically significant （ P〈0.05 ） .In the study group, there were 52 cases （ 86.7% ） of blood β2-mieroglobulin, 45 cases （ 75.0% ） of urine β2-microglobulin, the ratio of blood β2-mieroglobulin to diabetic nephropathy was higher than that of urinary β2-microglobulin, the difference was statistieally significant （P〈0.05） .Conclusion： Blood and urine β2-microglobulin has important diagnostic value to patients with early diabetic nephropathy, and it is worthy to be widely used in clinical practice.