慢性心力衰竭患者外周血清CA125水平与NT-proBNP水平、心功能的相关性研究

Correlational Study of CA125 and NT-pro BNP Level and Cardiac Function in Patients with Chronic Heart Failure

目的:研究并探讨慢性心力衰竭患者外周血清糖类抗原125(carbohydrate antigen 125,CA125)和N末端脑钠肽前体(N-terminal pro brain natriuretic peptide,NT-pro BNP)水平与心功能之间的相关性。方法:选取本院在2013年1月-2016年12月收治的150例慢性心力衰竭患者为观察组,按照心功能分级将患者分为心功能Ⅰ~Ⅱ级47例、Ⅲ级52例、Ⅳ级51例;另选取同期在本院门诊接受体检的健康者50例为对照组,观察组患者与对照组体检者均接受血液采集,测定其血清CA125水平、NT-pro BNP水平,通过心脏彩超测心功能指标,比较两组的检测结果,并计算血清CA125与NT-pro BNP、心功能之间的相关性。结果:观察组患者的血清CA125水平、NT-pro BNP水平均高于对照组,LVEF、SV均低于对照组,比较差异均有统计学意义(P<0.05);不同心功能分级患者之间的血清CA125水平、NT-pro BNP水平、心功能指标比较,差异均有统计学意义(P<0.05);血清CA125与NT-pro BNP呈正相关,与LVEF、SV呈负相关,即与心功能呈负相关。结论:慢性心力衰竭患者的血清CA125水平与其NT-pro BNP水平、心功能密切相关,可在一定程度上反映患者的病情进展,为慢性心力衰竭患者的病情评估提供借鉴。

Objective： To study and explore the correlation of serum carbohydrate antigen 125 （ CA125 ） and N terminal pro brain natriuretic peptide （ N-terminal pro brain natriuretie peptide, NT-proBNP ） level and heart function in patients with chronic heart failure.Method： From January 2013 to December 2016, 150 cases with chronic heart failure who treated in our hospital were selected as the observation group, according to the classification of cardiac function they were divided into cardiac function Ⅰ-Ⅱ grade （ 47 cases ）, Ⅲ grade （ 52 cases ） and Ⅳ grade （ 51 cases ） ; 50 healthy cases who received physical examination in our hospital were selected as control group, the cases in the observation group and the control group both were collected blood for determination of the serum CA125 level, NT-proBNP level, the determination of cardiac function index were examined by echocardiography, the heart function indexes were tested by heart color Doppler ultrasound, and the results of two groups were compared, the correlation between serum CA125 and NT-proBNP, cardiac function were calculated.Result： The CA125 level, NT-proBNP level of the observation group both were higher than those of the control group, the LVEF, SV of the observation group were all lower than those of the control group, the differences were statistically significant （ P〈0.05 ） ; the CA125 level, NT-proBNP level, cardiac function indexes of different grades had statistic significant （ P〈0.05 ） ; the serum CA125 level was positively correlated with the NT-proBNP, and was negatively correlated with the LVEF, SV, means negatively correlated with heart function. Conclusion： The serum CA 125 level is closely related to NT-proBNP level and the cardiac function in patients with chronic heart failure, which can reflect the progress of the patients＇ condition to some extent, provide reference for the diagnosis assessment of patients with chronic heart failure.