拉科酰胺对难治性癫痫患者认知功能和生活质量的影响

Effect of lacosamide on cognitive function and quality of life in patients with intractable epilepsy

目的探讨拉科酰胺作为抗癫痫辅助用药对难治性癫痫患者认知功能和生活质量的影响。方法收集2013年6月至2015年6月我院年龄18~75岁的80例难治性癫痫患者,随机分为辅以拉科酰胺干预组(干预组)及安慰剂对照组(对照组),并对患者进行10个月随访。干预前后对患者认知功能及生活质量进行评估。结果干预组10个月后的MMSE(Mini-mental state examination,简易精神状态检查)评分及WCST(Wisconsin Card Sorting Test,威斯康辛卡片分类测验)结果均优于对照组,差异有统计学意义(P<0.05)。干预组治疗后患者QOLIE-31总分、对发作的担忧、认知功能及综合生活质量评分均较治疗前增高(P<0.05),且高于对照组(P<0.05)。结论拉科酰胺不引起癫痫患者认知功能减退,且能改善患者主诉的生活质量。

Objective To investigate the effect of lacosamide as an adjuvant drug on cognitive function and quality of life in patients with intractable epilepsy. Methods Eighty intractable epilepsy patients aged 18 to 75 years in our hospital were collected from June 2013 to June 2015, and they were randomly divided into lacosamide intervention group （intervention group） and placebo control group （control group） ;all patients were followed up for 10 months. The cognitive function and quality of life were evaluated before and after intervention with lacosamide. Results MMSE score and WCST test of intervention group after 10 months were better than control group, the difference being significatn （ P 〈 0. 05 ）. After treatment, QOLIE-31 total score, seizure concerns, cognitive function, and the comprehen- sive quality of life score of intervention group increased, which were higher than that of control group （ P 〈 0. 05 ）. Conclusion Lacosamide does not cause cognitive dysfunction in patients with epilepsy and can improve the patients＇ quality of life.