老年患者大肠埃希菌尿路感染现状及耐药性分析

Elderly patients with Escherichia coli urinary tract infection and analysis of their drug resistance

目的了解老年患者大肠埃希菌尿路感染的感染现状及耐药性特征,为临床治疗及合理使用抗菌药物提供理论依据。方法收集我院2013年1月至2015年12月65岁及以上住院患者送检的中段清洁尿标本,从中培养出444株大肠埃希菌,采用回顾性分析方法进行感染现状及耐药性分析。结果美罗培南及厄他培南耐药率最低,亚胺培南其次,耐药率高于70%的抗生素分别为哌拉西林、氨苄西林、加替米星、头孢唑林、头孢唑喃钠、头孢噻吩、环丙沙星、罗米沙星、左氧氟沙星、左旋氧氟沙星、氨苄西林/舒巴坦。结论老年患者大肠埃希菌尿路感染现状较为严峻,从尿液标本中分离出的大肠埃希菌耐药率较高,应根据药敏试验结果合理使用抗菌药物。

Objective To investigate the infection status and antibiotic resistance of Escherichia coli urinary tract infection in elderly patients, and to provide theoretical basis for clinical treatment and rational use of antibiotics. Methods The middle of clean urine specimens was collected from hospitalized patients 65 years old and above in our hospital from January 2013 to December 2015. Totally 444 strains of Escherichia coli were cultured and the infection status and drug resistance were analyzed by retrospective analysis. Results The resistance rate to meropenem and itapenem was the lowest,followed by imipenem. The antibiotics with resistance rates higher than 70% included piperacillin, ampicillin, galimicin, cefazolin, cefazolin sodium, cefotaxime, ciprofloxacin, levofloxacin, levofloxacin and levofloxacin, and ampicillin/sulbactam. Conclusion Escherichia coli urinary tract infection is more severe in elderly patients, and the drug resistance rate of Escherichia coli isolated from urine specimens is higher. Rational use of antibiotics should be based on the results of drug sensitivity test.