基于网络药理学方法探讨瑶药四方藤抗类风湿性关节炎的作用机制

Exploration of the mechanisms of Cissus pteroclada Hayata anti-rheumatic arthritis basing on network pharmacology

文章运用反向分子对接的手段探讨四方藤抗类风湿性关节炎的机制。选择四方藤中11个主要化学成分,应用Chem Bio Draw软件画出化学结构式,通过Pharm Mapper数据库分析预测潜在作用靶点,运用DAVID和KEGG数据库预测其作用通路信息,并构建四方藤作用机制网络。得到EGFR,MAPK1 PDPK1等四方藤主要成分作用靶点122个,并聚焦到21条相关通路,这些通路主要与炎症反应、糖尿病、癌症相关。结果表明,瑶药四方藤抗类风湿性关节炎作用可能与炎症反应中的相关靶点和通路有关。

Study on the mechanism of anti rheumatoid arthritis by using molecular docking.Select 11 main chemical components from the Cissus pteroclada Hayata,use ChemBioDraw software to draw the chemical structure,then predict of potential targets by PharmMapper database.Using DAVID and KEGG database to predict its pathway information,and to establish thegraph of Cissus＇mechanisms network.In the end,we get 122 maintargetslike EGFR,MAPK1,PDPKland so on,some of the targets focus on 21 related pathways.These pathways are associated with inflammation,diabetes,and cancer.The results showed that the effect of Cissus pteroclada Hayataanti-rheumatoid arthritis on rheumatoid arthritis may be related to the target and pathway of inflammation.