同型半胱氨酸在肾病领域的研究进展

Study Progress of Homocysteine in Nephropathy

同型半胱氨酸(Hcy)是一种含硫氨基酸,是心血管疾病的独立风险因子。肾病患者为心血管疾病的高发人群,肾病患者中Hcy升高也很普遍。肾病患者Hcy升高的机制尚不明确,肾脏是Hcy代谢的重要器官,肾脏的结构功能异常导致Hcy清除减少,可能为Hcy升高的主要原因。Hcy升高后可进一步导致肾脏损伤,进而造成Hcy升高和肾脏损伤之间的恶性循环。叶酸、维生素B族等药物能降低Hcy水平,但在肾病患者中Hcy水平的下降并不能改善患者预后和预防心血管事件。

Homocysteine （Hey） is a sulfur-containing amino acid, which is an independent risk factor for cardiovascular disease. Nephropathy patients have high risk of cardiovascular disease, and elevated Hcy levels are also common in patients with nephropathy. The mechanism of Hey elevation in patients with kidney disease is unclear. Kidney is the most important organ of Hcy metabolism, and the abnormalities of kidney structure and function lead to a reduction in Hcy clearance,which may be the main reason for the rise of Hey. Elevated Hcy may cause progressive kidney damage, leading to a vicious cycle between Hcy and kidney damage. Folio acid,vitamin B family and other drugs can reduce Hcy level, but decreasing Hcy in nephropathy patients cannot improve the prognosis and prevent cardiovascular events.