国内儿童功能性便秘患病率和纤维素治疗有效性的文献评价

Meta-analysis of Prevalence and Cellulose Therapy for Functional Constipation of Children in China

目的:评价国内儿童功能性便秘的患病率和纤维素治疗的疗效。方法:计算机检索Pub Med、EMBASE、中国生物医学文献数据库(CBM)、中国期刊全文数据库(CNKI)、中国科技期刊全文数据库(VIP)、万方数据库,全面收集国内儿童功能性便秘患病率和纤维治疗功能性便秘的研究,采用Meta-analyst软件进行Meta分析。结果:共纳入8项患病率研究(84080例患者),Meta分析结果显示,功能性便秘总患病率为6.0%,95%CI(0.025~0.134)。同时纳入9项纤维治疗功能性便秘的研究(750例患者),结果显示,小麦纤维添加治疗能有效治疗功能性便秘[RR=1.49,95%CI(1.13,1.96),I^2=97%]。结论:国内儿童功能性便秘的患病率较高,小麦纤维素是治疗功能性便秘的有效药物,但由于受到纳入研究数量和质量的限制,有待进一步研究证实。

Objective： To analyze the prevalence and the efficacy of cellulose therapy for functional constipation （FC） of children in China. Methods： We surfed on PubMed, EMBASE, CBM, CNKI, VIP and Wanfang databases, comprehensively collected the studies on the prevalence of FC and the efficacy of cellulose therapy for FC of children, and carried out Meta-analysis using Meta-analyst software. Results： Metaanalysis showed that the total prevalence of FC in China's Mainland was 6.0%, accounting for 95% CI （0.025- 0.134） among the 8 included studies （84080 patients）. Meta-analysis also showed that there was significant difference for the efficacy rate between wheat cellulose groups and open control group during the treatment period[RR=l.49, 95%CI （1.13, 1.96） 12=97%] among 9 included studies （750 patients） of evaluating the efficacy of fiber therapy for FC. Conclusion： The prevalence of FC of children in China is relatively high. The wheat cellulose is an effective drug for the treatment of FC. The results need to be confirmed by additional studies due to the limitations of the quantity and quality of the study.