8种胃癌化疗药物与药品不良反应的聚类关系分析

Cluster Analysis of Eight Kinds of Gastric Cancer Drugs and Adverse Drug Reactions

目的:分析胃癌化疗药物不良反应与药品品种间的聚类关系,促进临床安全合理用药。方法:收集109家药品生产企业2010-2014年生产的8种胃癌化疗药物氟尿嘧啶、卡培他滨、表柔比星、顺铂、伊立替康、紫杉醇、奥沙利铂和多西他赛的不良反应报告数据,运用数据挖掘技术对药品不良反应与药品品种间的关系进行聚类分析,使用Clementine 14.1软件进行统计。结果与结论:共收集有效报告10572份,卡培他滨和顺铂,表柔比星和伊立替康,多西他赛和紫杉醇联合用药发生一般药品不良反应的可能性较大。卡培他滨、顺铂、伊立替康和表柔比星联合用药;多西他赛、氟尿嘧啶和紫杉醇联合用药时,出现严重药品不良反应的概率较高。瘙痒、过敏性休克、顺铂、多西他赛在聚类过程中的运算比重较大。

Objective： To find the potential cluster relationship between drugs and adverse drug reactions, so as to build the cluster model and guide the clinical drug use. Methods： Reports of adverse reactions caused by 8 kinds of gastric cancer drugs were collected from 109 pharmaceutical producing enterprises during 2010-2014, including fluorouracil, capecitabine, epirubicin, irinotecan, cisplatin, paclitaxel, oxaliplatin and docetaxel. Data mining technology was used to build cluster model and clementine 14.1 was for statistical analysis. Results and conclution： 10,572 effective reports were collected and statistically analyzed, which showed that capecitabine combined with cisplatin, epirubicin with irinotecan, and docetaxet with paclitaxel were more likely to cause general adverse drug reactions. The combination of capecitabine, cisplatin, irinotecan and epirubicin, as well as the combination of docetaxel, fluorouracil and paclitaxel, was more likely to cause serious adverse drug reactions. Pruritus, anaphylactic, cisplatin and docetaxel were more important in the process of cluster analysis.