肉瘤样肝细胞癌是典型的上皮-间质转化肿瘤范例

Sarcomatoid hepatocellular carcinoma is an example of epithelial mesenchymal transition

目的:探讨肝细胞癌肉瘤样转化过程中上皮-间质转化相关标记的改变。方法:采用免疫组化方法检测肉瘤样肝细胞癌中肉瘤样区域和经典型肝细胞癌区域上皮-间质转化(epithelial to mesenchymal transition,EMT)相关标记表达。结果:与经典型肝细胞癌区域比较,肉瘤样区域上皮标记E-cadherin、β-catenin表达均下调,间质标记Vimentin表达上调。结论:典型肝细胞癌转化来的肉瘤样肝细胞癌发生了上皮-间质转化样分子改变,肉瘤样肝细胞癌是肿瘤进展过程中一个典型的EMT范例。

Objective：To investigate the changes of epithelial mesenchymal transition related markers in the process of hepatocellular carcinoma sarcomatoid transformation.Methods：Cases of sarcomatoid hepatocellular carcinoma with sarcomatous component and a carcinomatous component was studied by immunohistochemistry of En Vision two-step methods to detect the differentia of the related markers.Results：Compared with classic hepatocellular carcinoma components,carcinomatous components epithelial markers such as E-cadherin,β-catenin expression were de-regulated and mesenchymal markers such as Vimentin was up-regulated.Conclusion：Sarcomatoid hepatocellular carcinoma which arose from classic hepatocellular carcinoma underwent epithelial-mesenchymal-transition-like molecular change and sarcomatoid hepatocellular carcinoma is a typical example of epithelial mesenchymal transition.