艾司西酞普兰与文拉法辛治疗焦虑合并抑郁障碍患者的疗效比较

Comparison of escitalopram and venlafaxine in the treatment of patients with anxiety and depression

目的:评价艾司西酞普兰治疗焦虑合并抑郁障碍患者的临床疗效。方法:70例符合入组焦虑合并抑郁障碍标准的患者,随机分成对照组和研究组,对照组服用文拉法辛治疗,研究组服用艾司西酞普兰治疗,疗程均为6周,并用汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD)进行疗效评定,药物不良反应采用不良反应量表(TESS)评估。结果:研究组治愈率57.6%,高于对照组34.4%,差异有统计学意义(P<0.05)。研究组起效快,不良反应率低,与对照组比较,差异有统计学意义(P<0.05)。结论:艾司西酞普兰较文拉法辛治疗焦虑合并抑郁障碍共患效果好,不良反应低。

Objective：To evaluate the clinical efficacy of escitalopram in the treatment of patients with anxiety and depression.Methods：70 patients were randomly divided into control group and study group.The control group was treated with venlafaxine.The study group was treated with escitalopram,the course of treatment was 6 weeks.Hamilton Anxiety Scale（HAMA） and Hamilton Depression Scale（HAMD）were used to evaluate the efficacy and adverse drug reactions were evaluated by adverse reactions scale assessment（TESS）.Results：The cure rate of the study group was 57.6%,which was higher than that of the control group,the difference was statistically significant（P 〈 0.05）.The study group took effect quickly,and the adverse reaction rate was lower,compared with the control group,the difference was statistically significant（P 〈 0.05）.Conclusion：Escitalopram is more effective than venlafaxine in the treatment of anxiety and depression.