替米沙坦对高血压患者左室与心肌指标的影响

Effects of telmisartan on left ventricular and myocardial parameters in patients with essential hypertension

目的探讨原发性高血压患者采用替米沙坦治疗后左室舒张功能与心肌肥厚的变化。方法选择2015年10月-2016年10月阳江市阳东区人民医院收治的原发性高血压伴左室舒张功能不全及左室肥厚的患者52例,对其采用替米沙坦治疗。观察本组治疗前与治疗1个疗程后患者血压、左室舒张功能与心肌肥厚指标的变化。结果本组治疗后收缩压(SBP)、舒张压(DBP)水平均低于治疗前,差异具有统计学意义(P<0.05)。本组治疗后IVST、LVPWT、LVMI、LVDd、A峰及A/E指标均低于治疗前,差异具有统计学意义(P<0.05);E峰指标高于治疗前,差异具有统计学意义(P<0.05)。结论原发性高血压患者采用替米沙坦治疗具有显著的降压效果,且能够改善患者左室舒张功能,调节心肌肥厚指标。

Objective To investigate the changes of left ventricular diastolic function and myocardial hypertrophy in patients with essential hypertension after the treatment with telmisartan. Methods 52 patients with essential hypertension, left ventricular diastolic dysfunction and left ventricular hypertrophy treated in Yangdong District People＇s Hospital of Yangjiang City from October 2015 to October 2016 were selected.All patients were treated with telmisartan. The changes of blood pressure, left ventricular diastolic function and myocardial hypertrophy were observed before and after 1 course of treatment. Results The levels of SBP and DBP in the group were lower than those before the treatment,the differences were statistically significant（P〈0.05）. After treatment,the indexes of IVST,LVPWT,LVMI,LVDd,A peak and A/E were lower than those before treatment,the differences were statistically significant（P〈0.05）. E peak index was higher than that before treatment,the difference was statistically significant（P〈0.05）. Conclusion The treatment of telmisartan has significant antihypertensive effect on patients with essential hypertension, and this treatment can improve left ventricular diastolic function and regulate myocardial hypertrophy index.