地塞米松不同时间间隔鼓室内灌注在治疗突发性聋中的临床研究

Comparative study of intratympanic Dexamethasone injection for sudden deafness at different time intervals

目的:通过不同时间间隔鼓室内注射地塞米松治疗突发性聋的临床疗效对比,探讨鼓室内注射的适当时间间隔。方法:临床确诊160例突聋患者,除给予常规扩张血管、溶栓、高压氧治疗,同时给予鼓室腔内灌注地塞米松,按不同时间间隔分为3组。每日注射组:每日给予患耳鼓室腔内注射;隔日注射组:隔日注射;1周2次组:1周注射2次。另有全身使用激素组28例及未用激素组18例。共计206例患者。结果:每日注射组和隔日注射组疗效差异无统计学意义,与1周2次组、全身使用激素组及未用激素组比较,差异有统计学意义。结论:鼓室腔注射地塞米松临床应用广泛,操作简单,疗效明显,每日及隔日一次注射患者依从性好,疗效较1周2次明显,避免了全身使用糖皮质激素的不良反应,患者无明显痛苦,可推广应用。

Objective：Comparative study of intratympanic Dexamethasone injection for sudden deafness at dif- ferent time intervals. Method： One hundred and sixty cases which had been diagnosed sudden deafness were treated by vasodilatortrophic nerve drugs and high pressure oxygen and the same time dexamethasone injective in the mid- dle ear. Injection time intervals were divided into qd, qod, and twice a week. Contral group is not use dexametha- sone. Result：The cure rate of qd and qod groups were higher than twice a week group,and the difference was sta- tistically significant（P〈0.05）. Conclusion： Intratypanic Dexamethasone injection for sudden deafness qd or qod is effective and safe.