复方苦参注射液联合化疗对胃肠道恶性肿瘤患者血生化指标和生活质量的影响

Effect of compound Kushen injection combined with chemotherapy on blood biochemical index and quality of life of gastrointestinal cancer patients

目的探究复方苦参注射液联合化疗治疗胃肠道恶性肿瘤的临床疗效及对患者血生化指标、肿瘤标记物、免疫功能和生活质量的影响。方法回顾性分析78例胃肠道恶性肿瘤患者,依据治疗方式的不同分为治疗组(n=39)和对照组(n=39)。治疗组采用复方苦参注射液联合化疗治疗,对照组仅采用化疗治疗。统计并比较2组患者治疗后的临床效果,检测并比较治疗前后2组患者血生化指标、肿瘤标记物和免疫功能的变化,采用SF-36量表对2组患者的生活质量进行评估。结果较对照组,治疗组的总有效率显著升高(P<0.05);治疗后2组S100A4、MMP-2、TNF-α和VEGF等血生化指标水平,CEA、CA724和CA199等肿瘤标记物指标水平较治疗前均显著下降,且治疗组显著低于对照组(P<0.05或P<0.01);治疗后2组CD3+、CD4+、NK细胞比例和CD4+/CD8+较治疗前均显著提高,CD8+细胞比例较治疗前显著下降,且2组间差异有统计学意义(P<0.05或P<0.01);治疗后2组SF-36各维度评分较治疗前均显著提高(P<0.05或P<0.01),且治疗组显著高于对照组(P<0.01)。结论复方苦参注射液联合化疗治疗胃肠道恶性肿瘤,患者免疫功能得到有效改善,同时能明显提高生活质量。

Objective To explore the effect of compound Kushen injection combined with chemotherapy in the treatment of gastrointestinal cancer patients and blood biochemical indexes, tumor markers, immune function and quality of life. Methods Retrospective analysis of 78 cases of gastrointestinal cancer patients in our hospital, according to the different treatment methods, all patients were divided into treatment group and control group, each group were 39 patients. The treatment group was treated with compound Kushen injection combined with chemotherapy, and the control group was treated only with chemotherapy. Compared the clinical effect of two groups after treatment; Detected and compared the changes of blood biochemical indexes and immune function of the two groups before and after treatment; To use SF-36 scale assessed the quality of life of the two groups. Results Compared with the control group, the total effective rate of treatment group was significantly higher （P 〈 0.05）; The S 100A4, MMP-2, TNF-α,VEGF, CEA, CA724 and CA199 of two groups after treatment were significantly lower than those before treatment, and the treatment group was significantly lower than the control group （P 〈 0.05 or P 〈 0.01）; Compared with those before treatment, the proportion of CD3＋, CD4＋, CD4＋/CD8＋ and NK cells ratio in the two groups were significantly improved after treatment, while the CD8＋ cells ratio was significantly decreased compared with those before treatment, and the difference between the two groups was significant （P 〈 0.05 or P 〈 0.01）; After treatment, the scores of SF- 36 in the two groups were significantly higher than before treatment （P 〈 0.05 or P 〈 0.01）, and the scores of SF-36 in the treatment group was significantly higher than that in the control group （P 〈 0.01）. Conclusion Compound Kushen injection combined with chemotherapy in the treatment of gastrointestinal cancer patients has significant clinical effect, which can effectively protect the immune function, and improve the quality of life significantly.