复发性尿路感染引起肾小管损伤的中医药治疗进展

Development of traditional Chinese medicine treatment of renal tubular injury caused by recurrent urinary tract infection

目的探讨中医药治疗复发性尿路感染引起肾小管损伤的临床疗效。方法查阅近五年中药复方或中成药治疗复发性尿路感染的临床研究文献,并综合性评价中医药治疗复发性尿路感染引起肾小管损伤的临床疗效。结果通过加味猪苓汤、清心莲子饮、二丁二仙汤、泌淋胶囊、肾舒颗粒、三金片等中药治疗,患者肾小管损伤的相关指标显著改善(P<0.05),6个月复发率为10.0%~32.6%。结论复发性尿路感染的中医病机主要是湿热蕴结、脾肾亏虚,久则气滞血瘀,损伤肾络,故临床多用茯苓、泽泻、车前子、牡丹皮、党参、黄芪、仙茅、淫羊藿等清热利湿,活血化瘀,健脾补肾。

Objective To explore the clinical effect of traditional Chinese medicine in the treatment of renal tubular injury caused by recurrent urinary tract infection. Methods Review the clinical research literature about the treatment of recurrent urinary tract infection with traditional Chinese medicine or Chinese patent medicine in recent five years and and evaluate its clinical efficacy. Results The study found that after the Chinese medicine treatment such as Jiawei Zhuling decoction, Qingxin Lianzi dicoction, Erding Erxian decoction, Miling capsule, Shenshu granule, Sanjin pills and so on, the correlation index of renal tubular injury improved significantly （P 〈 0.05）, 6 months recurrence rate was from 10% to 32.6%. Conclusion The pathogenesis of recurrent urinary tract infections is mainly retention of damp- heat,deficiency of spleen and kidney, qi stagnation and blood stasis, damaged kidney collateral. So, ruling, Zexie, Cheqianzi, Mudanpi, Dangshen, Huangqi, Xianmao, Xianlingpi and other drugs are often used in clinical to clear away heat-dampness,activate blood and absorb clots strengthen spleen and kidney.