药物流产后加服米非司酮预防蜕膜残留的剂量比较

Comparison of the Dose of Mifepristone in the Prevention of the Residual Drug Abortion After Drug Abortion

目的药物流产后加服不同剂量的米非司酮对预防蜕膜残留的临床效果。方法选取2016年1月至10月于佛山三水区人民医院行药物流产的1200例妇女作为研究对象,随机分成4组,即对照组、A组、B组、C组各300例。A组妇女药流后第1 d早晚各加服米非司酮25 mg,共50 mg;B组妇女药流后第1~3 d早晚各加服米非司酮25 mg,共150 mg;C组妇女于药流后第1~5 d早晚各加服米非司酮25 mg,共250 mg,对照组妇女药流后不加服米非司酮。观察4组妇女药流后组织蜕膜残留情况。结果 A、B、C组与对照组相比,均具有统计学差异(P<0.05);与对照组相比,A、B、C组妇女组织蜕膜残留情况明显更好(P<0.05);且B组妇女组织蜕膜残留情况优于A、C两组(P<0.05)。结论用米非司酮加米索前列醇对妇女成功实施药物流产后,连续3 d加服米非司酮(50 mg/d)能有效预防蜕膜残留,在一定程度上减少药物流产后蜕膜残留的几率,值得临床推广。

Objective To prevent the effect of different doses of mifepristone on the prevention of residual drug abortion after drug abortion.Methods 1200 women with drug abortion in Sanshui District People’s Hospital of Foshan from January 2016 to October were randomly divided into 4 groups：control group,A group,B group and C group,300 cases in each group.Group A women in after drug abortion 1 day sooner or later each plus mifepristone 25 mg,a total of 50mg;Group B women in after drug abortion 1-3days sooner or later each plus mifepristone 25 mg,a total of 150 mg;Group C women in after medical abortion 1-5 days sooner or later each plus service mifepristone 25 mg,a total of 250 mg,control group drug abortion without clothing and our ketone.To observe the decidua of 4 groups of women after drug residues.Results Compared with the control group,the B,A and C groups were significantly better（P〈0.05）,and the residue of the B group was better than that of A and C two groups（P〈0.05）.Conclusion The women in drug abortion with mifepristone plus misoprostol after continuous 3D mifepristone（50mg/d）can effectively prevent the risk of decidual residue,to a certain extent,reduce the rudimental decidua after medical abortion,worthy of promotion.