探讨垂体腺瘤对男性性功能的影响——回顾分析160例临床资料

Effects of pituitary adenomas on male sexual function: a multivariate analysis

目的通过临床资料分析,探讨垂体腺瘤对男性性功能的影响。方法通过2013年5月至2015年3月我院收治的160例男性垂体腺瘤患者的临床资料,从垂体腺瘤大小、病理分型、肿瘤侵蚀性和血清睾酮水平对性功能的影响进行分析。结果垂体微腺瘤术后性功能障碍(SD)恢复正常率100%,大腺瘤患者性功能障碍恢复正常率31.7%,巨大腺瘤患者性功能障碍恢复正常率20.5%,三组组间比较差异有统计学意义(P<0.05);肿瘤是否侵蚀性与术后性功能恢复无关(P>0.05)。功能性垂体腺瘤患者术前SD发生率与术后SD残留率比较差异无统计学意义(P>0.05),而无功能性垂体腺瘤患者术前SD发生率与术后SD残留率比较差异有统计学意义(P<0.05)。垂体腺瘤患者术后血睾酮水平与SD改善有关(P<0.05)。结论垂体腺瘤的体积大小、病理类型成为垂体腺瘤患者SD的影响因素,血清睾酮水平即是衡量患者术后性功能恢复情况的重要指标。

Objective To explore the effect of pituitary adenoma on male sexual function through clinical data analysis. Methods The clinical data of 160 patients with pituitary adenoma from May 2013 to March 2015 were analyzed. The effects of pituitary adenoma size, pathologic type, tumor erosivity and serum testosterone level on sexual function were analyzed. Results The normal rate of postoperative dysfunction （SD） of pituitary microadenoma was 100%. The normal rate of sexual dysfunction in patients with large adenoma was 31.7%, and the normal rate of sexual dysfunction was 20.5% in the patients with giant adenoma. The difference was statistically significant （P 〈0.05）; whether the tumor erosivity and postoperative functional recovery has nothing to do （P〉 0.05）. There was no significant difference in SD incidence and postoperative SD residual rate between the patients with functional pituitary adenoma （P〉 0.05）, but there was no significant difference between SD incidence and SD residual rate in patients without functional pituitary adenoma Statistically significant （P 〈0.05）. The level of serum testosterone in patients with pituitary adenomas was associated with improved SD （P〈0.05）. Conclusion The volume and pathological type of pituitary adenoma are the influencing factors of SD in patients with pituitary adenoma. Serum testosterone level is an important index to measure the recovery of postoperative sexual function.