术前抑郁对全麻腹腔镜结肠癌患者术后早期认知功能的影响

Effect of preoperative depression on early postoperative cognitive function in laparoscopic colon cancer patients during general anesthesia

目的 探究术前抑郁对全麻腹腔镜结肠癌患者术后早期认知功能恢复的影响。方法 选择2015年5月至2016年4月在浙江大学医学院附属邵逸夫医院住院并择期行全麻下腹腔镜结肠癌根治术患者150例，男70例，女80例，年龄50-85岁，ASA Ⅰ-Ⅱ级。评估术前抑郁状态[抑郁自评量表（SDS）]和术后认知功能1 d、3 d和7 d恢复情况[评估量表（PQRS）]，用Logistic回归分析术后认知恢复不良的危险因素。结果 共115例（76.7%）发生术后认知功能恢复不良。重度抑郁增加术后认知恢复不良风险（OR 1.295, 95% CI 1.012-13.184, P＝0.048）。结论 术前重度抑郁是增加术后认知功能恢复不良的独立危险因素。

Objective To analyze the effect of preoperative depression on early postoperative cognitive function after general anesthesia during laparoseopic colon cancer surgery. Methods One hundred and fifty ASA Ⅰ-Ⅱ general aneasthesia patients （male70, female 80）from Sir Run Run Shaw Hospital in May of 2015 to April of 2016, aged 50 -85, undergoing selective laparoscopic colon cancer patients were included. Evaluated preoperative depression by self-rating depression scale and evaluated postoperative cognitive function on 1,3,7 days by post-operative quality recovery scale. Use the multi-factor logistic regression to select the risk factors. Results There were 115 （76. 7% ） patients occurred poor cognitive function. According to SDS, The results of logistic regression analysis showed that the＇risk factors for postoperative poor cognitive function was severe depression （OR 1. 295, 95% CI 1. 012 -13. 184, P = 0. 048）. Conclusion Preoperative severe depression is a risk factor on postoperative cognitive function in laparoscopic colon cancer patients during general anesthesia.