系统性红斑狼疮生命质量量表反应度及可行性评价

Responsiveness and feasibility evaluation on quality of life instruments for patients with systemic lupus erythematos

目的对慢性病患者生命质量测定量表体系中的系统性红斑狼疮量表QLICD—SLE（V2．0）的反应度及可行性进行分析。方法用QLICD-SLE（V2．0）对143系统性红斑狼疮患者治疗前后的生命质量进行测量，采用传统假设检验并结合标准化反应均数、变化率、标准化效应大小等指标以及可行性分析方法进行分析。结果（1）治疗前后配对t检验表明：生理功能（t=2．39，P〈0．05）和特异性模块领域（t=2．22，P〈0．05）治疗后的QoL得分高于治疗前，差异有统计学意义，心理功能领域、社会功能领域及总量表得分在治疗后无明显改善；治疗后SES、SRM、CR各指标的变化均不太大。（2）大部分的病人可以比较好地理解本量表各条目的含义，而且在15-20min的时间内完成。问卷的回收率98．0％、完成率97．8％（有关性方面问题病人没有回答被认为合格）。结论该量表具有一定的反应度，有能力检测临床治疗效果，可行性好。

Objective To analyze and evaluate the responsiveness and feasibility of the quality of life instrument for patients with systemic lupus erythematos （SLE）. Methods 143 cases of SLE patients were measured by QLICD-SLE before and after treatment and the data were analyzed with the traditional hy- pothesis test and combining the effect size, standardized response mean, the relative efficiency, the standard effect size and the feasibility analysis methods. Results （ 1 ） Paired t test before and after treatment indica- ted that there were significant differences between after treatment and before treatment in physical（ t= 2.39, P〈0.05） and specific module domain （ t= 2.22, P〈0.05 ）, while there were no significant promotion in the scores of psychological function, social function and total score after treatment. There were no significant changes of SES, SRM and CR after treatment. （2）Most patients could understand the meaning of the instru- ment well and spent 15-20 minutes to finish it. The rate of recovery and completed were 98.0% and 97.8% respectively. Conclusions The QLICD-SLE can detect clinical change of treatment with good responsive- ness and feasibility.