不稳定型心绞痛患者采用硝酸甘油和地尔硫卓治疗的疗效及不良反应研究

Research of curative effect and adverse reactions by nitroglycerin and diltiazem in the treatment of unstable angina pectoris patients

目的探讨不稳定型心绞痛患者采用硝酸甘油和地尔硫卓治疗的临床效果及不良反应。方法 60例冠心病不稳定型心绞痛患者,依据治疗方案差异型将其分为常规组和观察组,各30例。常规组给予单纯硝酸甘油治疗,观察组给予硝酸甘油联合地尔硫卓治疗,对比两组的临床效果及不良反应发生情况。结果观察组不稳定型心绞痛控制率为96.7%,高于常规组的83.3%,差异具有统计学意义(P<0.05);观察组发作频率为(1.4±1.3)次/周、持续时间为(2.3±1.5)min/次,显著优于常规组的(2.8±1.4)次/周、(3.7±2.3)min/次,差异具有统计学意义(P<0.05);观察组不良反应发生率为6.7%,低于常规组的26.7%,差异具有统计学意义(P<0.05)。结论不稳定型心绞痛经硝酸甘油和地尔硫卓治疗,可降低心绞痛发作次数和时间,具有较高的借鉴意义。

Objective To investigate clinical effect and adverse reactions by nitroglycerin and dihiazem in the treatment of unstable angina pectoris patients. Methods A total of 60 patients with unstable angina pectoris were divided by different treatment measures into conventional group and observation group, with 30 cases in each group. The conventional group received nitroglycerin for treatment alone, and the observation group received nitroglycerin combined with dihiazem for treatment. Comparison was made on clinical effects and occurrence of adverse reactions between the two groups. Results The observation group had higher control rate of unstable angina pectoris as 96.7% than 83.3% in the conventional group, and their difference had statistical significance （P〈0.05）. The observation group had obviously better seizure frequency as （1.4 ± 1.3） times/week and duration time as （2.3 ± 1.5） mirdtime than （2.8 ± 1.4） times/week and （3.7± 2.3） min/time in the conventional group, and their difference had statistical significance （P〈0.05）. The observation group had lower incidence of adverse reactions as 6.7% than 26.7% in the conventional group, and their difference had statistical significance （P〈0.05）. Conclusion Nitroglycerin and dihiazem in treating unstable angina pectoris can reduce seizure frequency and duration time of angina pectoris, and this method contains highly referring significance.