脑外伤植物状态患者的核素^11C标记的氟马西尼正电子放射断层扫描观察

Detection of residual neuronal function in vegetative state patients after traumatic brain injury by using ^(11)C-FMZ PET

目的:探索核素^(11)C标记的氟马西尼(^(11)C-flumazenil,^(11)C-FMZ)正电子放射断层扫描(positron emission tomography,PET)检测脑外伤后植物状态患者残余神经元功能的应用价值。方法:收集我院脑外伤后植物状态患者4例(额叶外伤为主),正常志愿者7例(正常对照者),行^(11)C-FMZ PET显像,并对两侧大脑半球的皮质标准化摄取值(standardized uptake value,SUV)除以参考组织桥脑的SUV平均值,得到SUR比值(SUV ratio,SUVR),对比分析研究者及正常对照者的SUVR。结果:脑外伤后植物状态患者伤侧额叶、颞叶、顶叶、枕叶及大脑半球皮质SUVR(4.70、4.56、4.80、4.97、4.75)明显低于其对侧皮质(5.08、4.88、5.13、5.38、5.12)及正常对照者两侧大脑半球皮质(7.23、7.05、6.81、7.42、7.12)(P均<0.05)。结论:^(11)C-FMZ PET显像能够能观察脑外伤后植物状态患者的残余神经元功能。

Objective：To study the use of ^11C-FMZ PET in detecting residual neuronal function in vegetative state patients after traumatic brain injury. Methods：Four cases of vegetative state patients after traumatic brain injury were enrolled,and 7 normal volunteers were served as controls.^11C-FMZ PET was performed to detect the standardized uptake value（SUV） of cortex of both hemispheres. SUV ratio（SUVR） was obtained when SUV of the cerebral hemispheres was divided by SUV value of reference tissue,the pons. SUVRs of affected side and unaffected side were compared,as well as between patients and volunteers. Results：SUVRs of cerebral cortex of affected side were significantly lower than those of unaffected side and those of normal controls（P〈0.05）：frontal lobe（4.70 vs. 5.08,7.23）; temporal lobe（4.56 vs. 4.88,7.05）; parietal lobe（4.80 vs. 5.13,6.81）; occipital lobe（4.97 vs. 5.38,7.42）; cerebral hemisphere（4.75 vs. 5.12,7.12）.Conclusions：^11C-FMZ PET can be used to observe the residual neuronal function in vegetative state patients after trau-matic brain injury.