益肾泄浊汤治疗IgA肾病的临床观察

Clinical Observation of IgAN Treatment by Kidney-tonifying and Turbid-removing Decoction

目的观察益肾泄浊汤治疗气阴两虚型IgA肾病的临床疗效。方法将肾穿刺活检术病理确诊的IgA肾病患者63例随机分为治疗组和对照组,治疗组给予益肾泄浊汤加雷公藤多甙片和糖皮质激素,对照组给予雷公藤多甙片和糖皮质激素治疗,治疗6个月,观察中医临床证候、副作用、CCr及24小时尿蛋白定量。结果益肾泄浊汤可以改善IgA肾病患者的中医证候、减少激素的副作用及尿蛋白的排泄。结论益肾泄浊汤可以减少IgA患者的尿蛋白量及激素的副作用。

Objective： To observe the clinical effect of Kidney-tonifying and Turbid-removing Decoction on IgA ne- phropathy （IgAN） differentiated as both qi and yin deficiency. Method： Totally 63 cases of patients biologically diagnosed as IgA nephropathy （IgAN） by renal FNA were randomly divided into treatment and control groups; the treatment group received Kidney- tonifying and Turbid- removing Decoction combined with Glucosidorum Tripterygll Totorum and glucocorticoid, while the control group were given Glucosidorum Tripterygll Totorum and glucocorticoid with 6-month course to study the effect and side effect of Chinese medicine, CCr and quantitative analysis of 24-hour uric protein. Results： The experimental results showed that Kidney-tonifying and Turbid-removing Decoction could improve the symptoms of IgAN patients and reduce side effects of hormones as well as discharge of uric protein. Conclusion： Kidney-tonifying and Turbid-removing Decoction is effective in decreasing the amount of urinary protein in IgA patients and the side effects of hormones.