抗苗勒管激素表达水平与月经紊乱不孕症的关系

Association of the antimüllerian hormone levels with infertility in sterile females with menstrual disorders

目的探讨月经紊乱不孕症育龄妇女抗苗勒管激素(AMH)表达水平与不孕症的关系。方法将229例不孕症育龄期妇女分为月经正常不孕组(120例)和月经紊乱不孕组(109例)两组,并将月经紊乱不孕组患者分为经量增多、经量减少、经期延长、经期缩短各亚组;同时设对正常照组(160例)。用化学发光法检测各组血清AMH水平。结果相同年龄段月经紊乱不孕组患者的AMH水平明显低于月经正常不孕组(P<0.05)。与正常对照组比较,月经紊乱不孕组患者的血清AMH水平,显著降低(P<0.05)。月经紊乱不孕组各亚组中,经量减少和经期缩短亚组的AMH水平显著低于其他两亚组(P均<0.05)。结论月经紊乱不孕症患者的AMH表达水平明显偏低,其中以月经经期缩短和经量减少者最严重。因此,检测月经紊乱不孕症育龄女性血清AMH表达水平,可以为评估妇女生育潜力提供参考,从而给予及时治疗。

Objective： To investigate the relationship between the expression level of antimtlllerian hormone （AMH） and infertility in sterile females with menstrual disorders. Methods： 229 sterile females were divided into two groups according to whether menstruation was normal, and menstrual disorder group were further divided into 4 subgroups including menorrhagia, decreased menstruation, prolonged menstruation and shortened menstruation; while healthy women were selected as control group. The levels of serum AMH in all groups were detected by chemiluminescence. Results： The level of AMH in menstrual disorder group was significantly lower than that in normal menstruation group （P〈0.05） of the same age. Compared with the normal control group, the serum AMH level of the patients with menstrual disorders was significantly decreased （P〈0.05） . During the menstrual disorder subgroups, the decreased menstruation and shortened menstruation subgroups had the significantly decreased serum AMH level than the other two subgroups （all P〈0.05） . Conclusion： the level of AMH expression was significantly decreased in sterile females with menstrual disorders, especially in those with decreased menstruation and shortened menstruation. Therefore, to detect the level of serum AMH can provide reference for assessing fertility potential in women with menstrual disorders, so as to give such women timely treatment.