胚胎移植后4天血P水平与IVF-ET妊娠结局的相关性研究

Study of the correlation between serum progesterone and pregnancy outcome of IVF-ET on the 4th day after embryo transfer

目的探讨体外受精-胚胎移植(in vitro fertilization-embryo transfer,IVF-ET)过程中胚移植后4天血清孕激素(progesterone,P)与IVF-ET结局的关系。方法将研究对象根据妊娠结局分为妊娠组和非妊娠组,比较两组P差异;将研究对象根据P值分成3组(A组:P<50nmol/L,B组:50nmol/L<P<120nmol/L,C组:P>120nmol/L)分析3组间着床率、临床妊娠率、早期自然流产率差异。结果妊娠组与非妊娠组P差异无统计学意义(P>0.05),三组间着床率、临床妊娠率差异无统计学意义(P>0.05),B组早期自然流产率较A组和C组显著下降,差异有统计学意义(P<0.05)。结论胚胎移植后4天血清P水平与临床妊娠率无显著相关性,但P在50-120nmol/L之间早期自然流产率最低。

Objective： To investigate the influence of serum progesterone to pregnancy outcome of IVF-ET on the fourth day after embryo transfer. Methods： According to the outcome of pregnancy, the patients were divided into pregnancy group and non-pregnancy group, then compared the difference of P between the two groups; According to the serum P, the patients were divided into three groups （A group： P〈50nmol/L, B group： 50 nmol/L〈P〈120 nmol/L, C group： P〉120 nmol/L） , and reviewed focusing on the implantation rate, clinical pregnancy rate and early spontaneous abortion rate. Results： There were no statistical difference in the P between the pregnancy group and the non-pregnancy group （P〉0.05） . There were no statistical difference in the implantation rate, the clinical pregnancy rate among the three groups （P〉0.05） . The early spontaneous abortion rate of B group was significantly lower than that of A group and C group, the difference was statistically significant （P〈 0.05） . Conclusion： There was no significant correlation between the P and the clinical pregnancy rate on the fourth day after embryo transfer, however, the early spontaneous abortion rate was tower when the P between 50-120 nmol/L.