IVF周期中短时受精的安全性研究

The study of safety of short-term fertilization in IVF cycles

目的探索IVF周期中短时受精的安全性。方法回顾性分析2013年1月~2015年6月期间的IVF周期,比较和统计分析103例长时受精和122例短时受精的IVF周期中的受精率、正常受精率、多精受精率,优质胚胎率、妊娠率、种植率、流产率、宫外孕率及活产率。结果 (1)长时受精组和短时受精组女性患者的年龄、获卵数经统计无显著性差异(P>0.05)。实验组和对照组的受精率、正常受精率差异显著(P<0.01),多精受精率和优质胚胎率无显著性差异(P>0.05)。(2)新鲜移植后,长时受精组和短时受精组妊娠率、着床率、流产率、宫外孕率和活产率分别为59.4%/63.6%、57.4%/43.9%、10.5%/9.5%、5.3%/9.5%、50.0%/54.5%,经统计均无显著性差异(P>0.05)。(3)冷冻移植后,长时受精组和短时受精组妊娠率、着床率和活产率分别为56.7%/64.1%、38.0%/44.3%、10.5%/8.5%、5.3%/6.8%、47.8%/53.3%,经统计均无显著性差异(P>0.05)。讨论无论是新鲜移植或冷冻移植,短时受精同长时受精相比对妊娠结局均无显著差异性(P>0.05);从短期的临床数据来看,短时受精在临床的应用是安全可行的。

Objective： To explore the safety of short-term fertilization in IVF cycles. Methods： A retrospective statistical analysis was performed in our center on 103 long-term fertilization cycles and 122 short-term fertilization cycles from January 2013 to June 2015.The fertilization rate and normal fertilization rate had polyspermy rate, good quality embryo, pregnancy rate, embryo implantation rate, the rate of abortion, the rate of ectopic pregnancy and live birth rate were compared. Results. （ 1 ） The age of patient and number of retrieved oocytes had no significant difference （P〉0.05） in short-time fertiliazation group and long- term fertilization group. （2） The rate of pregnancy, embryo implantation, abortion, ectopic pregnancy and live birth after fresh transplantation in long-term fertilization group and short-term fertilization group were respectively 59.4%/63.6%, 57.4%/43.9%, 10.5%/9.5%, 5.3%/9.5% and 50.0%/54.5%. All of them had no significant difference （P〉0.05） . （3） The rate of pregnancy, embryo implantation, abortion, ectopic pregnancy and live birth rate after frozen transplantation in long-term fertilization group and short-term fertilization group were respectively 56.7%/64.1%, 38.0%/44.3%, 10.5%/8.5%, 5.3%/6.8% and 47.8%/53.3%. All of them had no significant difference （P〉0.05） . Conclusion： Whether fresh or frozen transplantation, short-term fertilization compared with long-term fertilization on pregnant outcomes were no significant differences （P〉0.05） ; Short-term fertilization has certain application value in clinic.