早期干预治疗与联合药物治疗在新生儿脑损伤患儿治疗中的疗效对比分析

Early Intervention With or Without Medication in Treatment of Neonatal Brain Injury: Comparative Analysis of Therapeutic Effect

目的:通过应用早期干预、早期干预联合神经营养类药物治疗新生儿脑损伤患儿中疗效的对比分析,选择更为合适、有效的针对新生儿脑损伤的临床疗法。方法:将232例脑损伤患儿(包括低体重儿、早产儿、HIE、不同程度窒息等)纳入试验组,对照组选取我院116例各项指标完全正常的新生儿,通过对比分析试验组不同治疗方案Gesell评测DQ值来衡量两种疗法的临床疗效优劣。结果:联合治疗组在治疗后表现出显著优势,与对照组相比各项指标稍低,但差异无统计学意义(P>0.05);较早期干预组相比显著高于其指标,差异有统计学意义(P<0.05);两组患儿治疗后均有显著好转,差异有统计学意义(P<0.05)。结论:在确诊新生儿存在脑损伤时,积极治疗占有着举足轻重的地位,可促进其发育商(DQ)的提高;且与早期干预相比,联合神经营养类药物能够更加有效地缓解新生儿脑损伤的情况。

Objective： Through the comparative analysis on the therapeutic effect of early intervention with or without neurotrophic drugs in treat- ment of neonatal brain injury, to choose a more appropriate and effective therapy for neonatal brain injury. Methods： 232 cases of newborns with brain injury （including infants of low-birth weight, premature birth, HIE, different degrees of asphyxia, etc） were involved in experimental group, while control group was 116 cases of healthy newborns with completely normal detected indexes, and compared the efficacy of the two methods （ear- ly intervention and combination with medication） by evaluating DQ with Gesell after different treatments in the two experimental groups. Results： Af- ter treatment, the combination group had showed significant advantages, of whom the indexes were slightly lower than those of control group, but the differences had no statistical significance （P〉0.05）; and compared with those of early intervention group, the indexes of combination group were significantly higher, the differences had statistical significance （P〈0.05）; the two groups of infants had significantly turned better after treatment, the dif- ferences had statistical significance （P〈0.05）. Conclusion： Aggressive treatment which can promote the improvement of developmental quotient （DQ） plays an important role when neonatal brain injury is diagnosed; and compare with early intervention, the combination with neurotrophic drugs can more effectively relieve neonatal brain injury.