四川省凉山州2011-2013年应用BED-CEIA法估算临床病人的HIV新发感染率

Estimation of HIV-1 Incidence with BED-CEIA among clinical patients in Liangshan Yi autonomous prefecture,2011-2013

目的了解四川省凉山彝族自治州医疗机构临床病人的艾滋病病毒(HIV)新发感染状况及流行趋势。方法 2011-2013年,在四川省凉山州通过医疗机构其他就诊者、受血制品前和术前检查所发现的全部HIV-1感染者为对象,采集样本进行BED-CEIA检测,估算临床病人的HIV新发感染率。结果 2011-2013年,凉山州医疗机构来源人群中共发现HIV抗体阳性病人6 087例,各年分别为1 843例、2 031例、2 213例,HIV-1阳性率分别为0.54%、0.68%和0.51%,新发感染率各为0.17%[95%可信区间(CI):0.15%~0.19%]、0.41%(95%CI:0.38%~0.45%)和0.31%(95%CI:0.29%~0.34%)。结论凉山州临床病人的新发感染率有所上升,艾滋病向一般人群扩散,应扩大艾滋病的防控范围。

Objective To estimate HIV-1 incidence and epidemic trend among clinical patients in Liangshan Yi autonomous prefecture. Methods To conduct BED test to all HIV-positive patients specimen from medical institutions who suffered other diseases or got HIV testing before reception of blood or blood products and surgery, and estimate HIV incidence. Results A total of 6078 clinical patients were diagnosed with HIV-1 infection from 2011 to 2013, with the numbers of 1843 in 2011, 2031 in 2012 , and 2213 in 2013. HIV-1 prevalence of the clinical patients was 0.54%, 0.68% and 0.51%, with the annual incidence of 0.17% （95% CI, 0. 15%-0. 19%）, 0.41%（95% CI, 0. 38%-0.45%） and 0.31% （95% CI, 0. 29%-0.34%）. Conclusion The incidence among the clinical patients in Liangshan Yi autonomous prefecture is increasing, HIV has spread to general population and the efforts on HIV control and prevention should continually be strengthened and scaled up.