人类单纯疱疹病毒的研究及治疗进展

Progress inresearch and treatment of human herpes simplex virus

单纯疱疹病毒(HSV)常感染生殖器皮肤黏膜而导致生殖器疱疹。HSV进入人体后可终生潜伏,在一定条件下可再度活跃而复发,进而常呈慢性反复发作的过程。HSV除引起生殖器疱疹外,还可在分娩时经产道感染新生儿,也常感染口腔、眼结膜。艾滋病病毒感染几乎总是伴随着疱疹病毒的感染,增加了艾滋病治疗的复杂性,治疗难度大、复发率高。因此,研发疱疹病毒的治疗药物及疫苗仍然是一个重要的问题。

Herpes simplex virus often infects the genital skin and mucosa sites, and this leads to genital herpes. Perpetually latent, this virus can be reactivated under certain conditions to cause the relapse of infection. The progress is often chronic and recurrent. In addition to genital herpes, the virus can infect newborns through birth canal during childbirth. Oral and conjunctival infection can also be resulted from this virus. HIV infection is almost always accompanied by herpes virus infection. It increases the complexity and difficulty of AIDS treatment and raises the recurrence rate. Therefore, the research and development of drugs and vaccines against HSV infection remains a clinical issue.