超声造影联合动态血压评价原发性高血压患者的价值分析

Analysis of the values of contrast-enhanced ultrasound combined with ambulatory blood pressure monitoring in patients with essential hypertension

目的 探讨超声造影联合动态血压评价原发性高血压患者的应用价值.方法 选择2013年2月到2015年12月在新疆医科大学第六附属医院诊治的单纯原发性高血压患者（对照组,n=125）和原发性高血压肾病患者（高血压肾病组,n=125）作为研究对象.两组都进行动态血压监测和超声造影检测,同时进行相关性分析.结果 高血压肾病组的24 h SBP、24 h DBP和24 h PP值[（88.28±0.44）mm Hg、（138.28±10.56）mm Hg和（57.39-±7.14）mm Hg]均明显高于对照组[（94.58±7.11）mm Hg、（147.29±19.44）mm Hg、（63.98±5.33）mmHg],差异有统计学意义（P＜0.05）.高血压肾病组的达峰时间明显多于对照组（P＜0.05）,而两组的峰值强度、曲线下面积、曲线尖度对比未见统计学差异（P＞0.05）.Spearman相关分析显示,高血压肾病患者24 h SBP、24 h DBP和24 h PP均与超声造影的达峰时间呈显著正相关（r=0.293、0.413、0.433,P＜0.05）;多因素Logistic逐步回归分析显示,24 h SBP、24 h DBP、达峰时间对高血压肾病有独立的预测价值（P＜0.05）.结论 超声造影联合动态血压评价原发性高血压肾病具有良好的相关性,可为高血压肾病早期诊断及防治提供新的思路,具有很好的应用价值.

Objective To investigate the values of contrast-enhanced ultrasonography combined with ambulatory blood pressure monitoring in patients with essential hypertension.Methods From February 2013 to December 2015,pure primary hypertension patients （control group,n =125） and primary hypertension nephropathy patients （hypertension nephropathy group,n=125） were selected in our hospital as the object of study,two groups were given the ambulatory blood pressure monitoring and ultrasonography detection,and were given the correlation analysis at the same time.Results The 24 h SBP,24 h DBP and 24 h PP values in the hypertension nephropathy group [（88.28±0.44）mm Hg,（138.28±10.56）mm Hg and （57.39±7.14）mm Hg] were significantly higher than those in the control group[（94.58±7.11）mm Hg,（147.29±19.44）mm Hg and （63.98±5.33）mm Hg],and the difference wee statistically significant （P〈0.05）.Compared with the control group,the peak time of the hypertensive nephropathy groupwere significantly higher than that of the control group （P〈0.05）,and there were no significant difference compared in the peak intensity,area under the curve （P〉0.05）.Spearman correlation analysis showed that in the patients with hypertensive nephropathy,24 h SBP,24 h DBP and 24 h PP were significant positive correlated to the ontrast-enhanced ultrasound peak time （r=0.293,0.413,0.433,P〈0.05）.Multiple logistic stepwise regression analysis showed that 24 h SBP,24 h DBP,peak time were the independent predictive index to the hypertensive nephropathy （P〈0.05）.Conclusion Contrast-enhanced ultrasound combined with ambulatory blood pressure monitoring in patients with essential hypertension have good correlation,which can provide a new idea for early diagnosis and prevention of hypertension,and it has a good application values.