选择性β受体阻滞剂与β受体阻滞血管扩张剂对高血压患者动脉僵硬度影响的系统评价

The effect of selective β blockers and vasodilating β blockers on arterial stiffness in hypertension： A systematic review

目的 系统评价选择性β受体阻滞剂与β受体阻滞血管扩张剂对高血压患者动脉僵硬度（AS）的影响.方法 计算机检索Pubmed数据库、EMbase数据库、Cochrane数据库、Web of Science数据库及中国生物医学文献数据库（CBM）,检索日期为各数据库建库时间至2016年7月14日止.纳入的试验类型为随机对照试验,采用Cochrane协作网的质量评价标准和软件RevMan 5.3进行资料分析.结局的效应指标为颈-股脉搏波速度（PWV）.结果 纳入随机对照试验4篇（197例患者）进行系统评价,所纳入的文献质量偏低.统计分析结果显示,选择性β受体阻滞剂与β受体阻滞血管扩张剂对高血压患者PWV作用比较（MI）=0.09,95％CI-0.25～0.42）,未见统计学差异.结论 新一代β受体阻滞血管扩张剂较选择性β受体阻滞剂对高血压患者AS的影响没有表现出优势.

Objective To systematically evaluate the effect of selective β blockers and vasodilating β blockers on arterial stiffness （AS） in hypertension.Methods Electronic searches were conducted in Pubmed,EMbase,Cochrane,Web of Science and CBM databases.The time for researches was from the beginning of databases establishment to July 14,2016.Randomized clinical trials were included in this review.The systematic review was performed using RevMan 5.3 and the assessment of methodological quality was done based on Cochrane handbook.Carotid-femoral pulse wave velocity （PWV） was evaluated as the outcome.Results 4 randomized controlled trials were included （involving 197 patients）,all trials included in this review were of poor quality.The result showed that the comparison between selective β blockers and vasodilating β blockers on AS had no differences （MD=0.09,95%CI-0.25-0.42）.Conclusion New generation vasodilating β blockers is not more effective than selective β blockers on AS in hypertension.