雷公藤多苷联合血尿方治疗紫癜性肾炎经验举隅

Experience in Tripterygium Glycosides Combined with Hematuria Presciption in the Treatment of Henoch-Schonlein Purpura Nephritis

紫癜性肾炎是儿科最为常见的继发性肾小球疾病之一,其发病机制为肾小球基底膜电荷屏障或机械屏障破坏,导致大量红细胞和蛋白漏出,临床表现为血尿和蛋白尿。丁樱教授根据多年临床经验,认为本病的发生与"热、虚、瘀"有关,血瘀贯穿病程始终,故以"扶正祛邪、养阴清热、化瘀止血并用"为治则。雷公藤多苷作为一种免疫抑制剂,具有消除蛋白尿的功效,血尿方则发挥其凉血止血,活血化瘀的功效。丁教授擅于将二者联用来治疗紫癜性肾炎血尿和蛋白尿型,并取得良好的临床疗效。

Henoch-Schonlein purpura nephritis is the most common pediatric secondary glomerular disease, pathogenesis of glomerular basement membrane potential harriers or mechanical barrier is damaged, resulting in a large number of red blood cells and the protein leakage, and the common clinical manifestations are hematuria and proteinuria. Professor Ding Ying based on years of clinical experience in treatment, she believes that the occurrence of the disease is related to heat, deficiency and stagnation, while static blood through the course, therefore, the rules of treatment are strengthening the body resistance to eliminate pathogenic factors, nourishing yin and clearing heat, as well as removing blood stasis and hemostasis. As an immunsuppressant, Tripterygium Glycosides can effectively eliminate proteinuria, while hematuria preseiption has an advantage in cooling blood and stanching blood and promoting blood circulation to remove blood. Professor Ding Ying is flexibility ues of both of them to treat Henoch-Schonlein purpura nephritis which belong to hematuria and proteinuria type, and obtained good clinical effect.