基于氧化石墨烯、适配体DNA及信号放大技术生物传感器的研究及应用

Integrating Graphene Oxide and Functional DNA for Amplified Biosensing

基于核酸适配体DNA和氧化石墨烯（graphene oxide,GO）的光学生物传感器因具有快速、准确及灵敏等优点,已越来越广泛地用于核酸、蛋白质及小分子底物的特异性检测.近年来的研究显示,将信号放大技术与适配体-GO检测方法结合可构建超高灵敏度的荧光光学生物传感器,实现痕量底物的特异性检测.文章综述了近年来氧化石墨烯、适配体DNA及核酸放大技术生物传感器的研究进展,以期为该类生物传感器的深入研究及大规模应用提供参考.

Integrating functional DNA probes with graphene oxide （GO） has proved to be a productive approach to the design of optical biosensors that detect nucleic acids, proteins or small-molecule targets with interest quickly, accurately and sensitively. In recent years, several elegant signal-amplification strategies uniquely applicable to optical DNA-GO biosensors were reported and these amplified biosensors were productively employed to achieve ultrasensitive detection of diverse targets. This review highlights notable achievements in this budding research field and provides a perspective on where the field is heading.