代谢综合征及其相关因子与肺血栓栓塞症的相关性研究

Study on correlation between metabolic syndrome and its related factors and pulmonary thromboembolism

目的探讨代谢综合征(MS)及其相关因子与肺血栓栓塞症(PTE)的相关性。方法 245例肺血栓栓塞住院患者作为肺血栓栓塞组(PTE组),同期200例健康体检者作为对照组,比较两组一般临床资料以及血压、体质量指数(BMI)、血糖、血尿酸、血清胆固醇、甘油三酯、高密度脂蛋白(HDL)和低密度脂蛋白(LDL)等资料。结果 PTE组和对照组MS患病率分别为12.65%和12.00%,差异无统计学意义(P>0.05);两组BMI比较,差异有统计学意义(P<0.05)。而高血压、高血糖或糖尿病、血尿酸、胆固醇、甘油三酯、HDL和LDL两组差异无统计学意义(P>0.05)。经多因素Logistic回归分析显示肥胖是肺栓塞的危险因子,OR(95%CI)为1.812(1.012,3.158)(P<0.05),MS、高血压、高血糖或糖尿病、血尿酸、胆固醇、甘油三酯、HDL和LDL等不是肺栓塞的影响因子(P>0.05)。将PTE组分成低危、中危和高危三个亚组,三亚组MS发生率差异无统计学意义(P>0.05)。三亚组BMI差异有统计学意义(P<0.05),高危组和中危组BMI高于低危组(P<0.05);MS、高血压、高血糖或糖尿病、血尿酸、胆固醇、甘油三酯、HDL和LDL比较,差异无统计学意义(P>0.05)。结论 MS与肺血栓栓塞症无相关性,肥胖是肺栓塞的危险因子,肥胖的肺栓塞患者的病情更严重。

Objective To explore the correlation between metabolic syndrome （MS） and its related factors and pulmonary thromboembolism （PTE）. Methods There were 245 pulmonary thromboembolism patients as pulmonary thromboembolism group （PTE group）, and concurrent 200 physical examination people as control group. Comparison were made on general clinical data, blood pressure, body mass index （BMI）, blood glucose, blood uric acid, se（um cholesterol, triglycerides, high-density lipoprotein （HDL） and low density lipoprotein （LDL） in two groups. Results PTE group and control group had prevalence rate of MS respectively as 12.65% and 12.00%, and the difference had statistical significance （P〉0.05）. Both groups had statistically significant difference in BMI （P〈0.05）. Both groups had no statistically significant difference in hypertension, high blood glucose or diabetes, blood uric acid, cholesterol, triglycerides, HDL and LDL （P〉0.05）. Multi-factor Logistic regression analysis showed that obesity was risk factor of pulmonary embolism, with OR （95%CI） as 1.812 （1.012, 3.158） （P〈0.05）, and MS, high blood glucose or diabetes, blood uric acid, cholesterol, triglycerides, HDL and LDL were not influencing factors of pulmonary embolism （P〉0.05）. PTE group were divided into low-risk, medium-risk and high risk groups, and three subgroups had no statistically significant difference in incidence of MS （P〉0.05）. Three subgroups had statistically significant difference in BMI （P〈0.05）, and high risk group and medium-risk group had higher BMI than low-risk group （P〈0.05）. Three subgroups had no statistically significant difference in MS, hypertension, high blood glucose or diabetes, blood uric acid, cholesterol, triglycerides, HDL and LDL （P〉0.05）. Conclusion MS is not correlated with pulmonary thromboembolism, and obesity is risk factor of pulmonary embolism. The pathogenetic condition of obese patients with pulmonary embolism is more serious.