幽门螺杆菌感染与复发性过敏性紫癜的关系

Correlation between helicobacter pylori infection and recurrent allergic purpura

目的探究幽门螺杆菌(Hp)感染与复发性过敏性紫癜之间的相关性。方法 60例复发性过敏性紫癜患儿作为观察组,60例体检的健康儿童作为对照组,对两组受检对象进行Hp检测,对比两组患儿的Hp阳性率,对比观察组Hp阳性与阴性患儿的腹痛发生率。观察组60例患儿根据Hp检测结果将分为Hp阳性和Hp阴性中,其中Hp阳性中部分患儿未采用抗Hp治疗,仅单一采用常规过敏性紫癜治疗,设为A组,其余Hp阳性患儿采用抗Hp治疗+常规过敏性紫癜治疗,设为B组;Hp阴性患儿采用常规过敏性紫癜治疗,设为C组。对比三组患儿的治疗总有效率。结果观察组患儿的Hp阳性率71.67%明显高于对照组健康儿童的25.00%,差异有统计学意义(P<0.05);观察组中Hp阳性患儿的腹痛发生率69.77%高于Hp阴性患儿的41.18%,差异有统计学意义(P<0.05);A组患儿的治疗总有效率75.00%明显低于B组的95.65%和C组的88.24%,差异有统计学意义(P<0.05)。结论 Hp感染与复发性过敏性紫癜的发病之间存在一定的相关性,Hp感染可能诱发过敏性紫癜的复发,在临床治疗中还需加强抗Hp治疗,改善预后,预防病情的反复发作。

Objective To explore the correlation between helicobacter pylori （Hp） infection and recurrent allergic purpura. Methods There were 60 recurrent allergic purpura children as observation group, and 60 healthy children with physical examination as control group. Hp was detected in two groups. Comparison were made on Hp positive rate in two groups, and incidence of stomachache between Hp positive and negative children in observation group. The observation group was divided into Hp positive and Hp negative children. There were some cases received conventional Henoch-Scb6nlein purpura treatment without anti Hp treatment in Hp positive cases as group A, and the other Hp positive cases received anti Hp ＋ conventional Henoch-Schgnlein purpura treatment as group B. 17 Hp negative cases received conventional Henoch-Schonlein purpura treatment as group C. Total treatment effective rate was compared in two groups. Results The observation group had obviously higher Hp positive rate as 71.67% than 25.00% in the control group, and the difference had statistical significance （P〈0.05）. The observation group had higher incidence of stomachache in Hp positive cases as 69.77% than 41.18% in Hp negative cases, and the difference had statistical significance （P〈0.05）. Group A had obviously lower total treatment effective rate as 75.00% than 95.65% in group B and 88.24% in group C, and their difference had statistical significance （P〈0.05）. Conclusion Hp infection has certain correlation with recurrent allergic purpura, and Hp infection may induce recurrence of allergic purpura. Anti Hp treatment should be strengthened in clinical treatment, so as to improve prognosis and prevent repeated attack of disease.