探讨慢性肺炎衣原体感染与慢性阻塞性肺疾病的关系

Exploration on correlation between chronic pneumonia choamydiae infection and chronic obstructive pulmonary disease

目的探索研究肺炎衣原体感染与慢性阻塞性肺疾病之间的关系。方法选取63例慢性阻塞性肺疾病患者为观察组,同期行健康检查的33例健康人为对照组。两组均行血清衣原体抗体免疫球蛋白(Ig)A、IgM、IgG以及对痰液中肺炎衣原体脱氧核糖核酸(DNA)进行检测。结果两组IgG阳性率比较,差异无统计学意义(P>0.05);观察组IgA阳性率为84.13%,明显高于对照组的42.42%,差异有统计学意义(P<0.05)。对照组中有2例PCR检测结果为阳性,阳性率为6.06%,观察组患者中有19例患者PCR检测结果为阳性,阳性率为30.16%;观察组肺炎衣原体PCR阳性率明显高于对照组,差异有统计学意义(P<0.05)。观察组患者衣原体感染率明显高于对照组,差异有统计学意义(P<0.05)。结论肺炎衣原体感染在慢性阻塞性肺疾病患者中发病率较高,肺炎衣原体感染可能为慢性肺阻塞性疾病的病因之一。

Objective To explore and study the correlation between chronic pneumonia choamydiae infection and chronic obstructive pulmonary disease. Methods There were 63 chronic obstructive pulmonary disease patients as observation group, and concurrent 33 physical examination people as control group. Detection were made on serum chlamydial antibody immunoglobulin （Ig）A, IgM, IgG and pneumonia chlamydia desoxyribonucleic acid （DNA） in sputum between two groups. Results Both groups had no statistically significant difference in IgG positive rate （P〉0.05）. The observation group had obviously higher IgA positive rate as 84.13% than 42.42% in the control group, and the difference had statistical significance （P〈0.05）. The control group had 2 cases with positive PCR detection results, with positive rate as 6.06%, while the observation group had 19 cases with positive PCR detection results, with positive rate as 30.16%. The observation group had obviously higher pneumonia choamydiae PCR positive rate than the control group, and the difference had statistical significance （P〈0.05）. The Observation group had obviously higher choamydiae infection rate than the control group, and the difference had statistical significance （P〈0.05）. Conclusion Pneumonia choamydiae infection has high morbidity in patients with chronic obstructive pulmonary disease, and pneumonia chlamydia infection may be one of the causes of chronic obstructive lung disease.