低水平甘油三酯增加脑出血患者全因死亡风险

Low Triglyceride is Associated with Increased All-cause Mortality of Intracerebral Hemorrhage

目的探究脑出血患者甘油三酯水平与全因死亡的相关性。方法本研究入选2000年至2001年期间467例经颅脑CT或核磁共振确诊为脑出血的患者并平均随访4.5年。依据甘油三酯(Triglyceride,TG)浓度是否在正常参考值范围将患者分为TG≤1.7mmol/L组(n=280)和TG>1.7 mmol/L组(n=187)。采集患者基线资料和静脉血标本,分析其基线资料和预后。终点事件为长期随访全因死亡。结果 467例脑出血患者长期随访中死亡110例,全因死亡率为23.6%。TG≤1.7 mmol/L组的全因死亡率(30%,84/280)明显高于TG>1.7 m mol/L组(13.9%,26/110),差异有统计学意义(log ran k P<0.001)。单因素Cox回归分析显示TG≤1.7 m mol/L增加死亡风险2.341倍(HR=2.341,95%CI 1.508~3.635,P=0.001)。经多因素Cox因素分析校正年龄和性别等因素后,TG≤1.7 mmol/L增加死亡风险(HR=1.984,95%CI 1.258~3.13,P=0.003)。结论 TG≤1.7 mmol/L增加脑出血患者全因死亡风险。

Objective To explore the relationship between triglyceride（TG） and all-cause mortality of patients with intracerebral hemorrhage. Methods We investigated 467 patients with CT or MRI confirmed diagnosis of intracerebral hemorrhage from 2000 to 2001, and prospectively followed up for a median of 4.5 years. TG≤1.7 mmol/L group, n=280 and TG〉1.7 mmol/L, n=187. The basic information were studied in all groups, the primary endpoint was all-cause death. Results The all-cause mortality was 23.6%. TG〈1.7 mmol/L group（30%, 84/280） had higher mortality than that in TG≤1.7 mmol/L group（13.9%,26/110）, P〈0.001. The univariate Cox regression analysis indicated that TG≤1.7 mmol/L had higher risk of all-cause mortality （HR=2.341, 95%CI 1.508-3.635, P=0.001）. With adjusted age, gender and other relevant factors, the low levels of TG （TG ≤1.7 mmol/L） were independently related to all-cause mortality of intracerebral hemorrhage（HR=1.984, 95%CI 1.258-3.13, P=0.003）. Conclusion Low levels of TG had increased the risk of all-cause mortality in patients with intracerebral hemorrhage.