加味苍附导痰汤合中药包热敷治疗肾虚痰湿型多囊卵巢综合征22例

Modified Cangfu Daotan Decoction Combined with Chinese Herbal Bag Hot Compress for Treatment 22 Cases of Kidney Deficiency and Phlegm Stagnation Type of Polycystic Ovary Syndrome

目的:观察加味苍附导痰汤联合中药包热敷治疗多囊卵巢综合征的临床疗效。方法:将40例肾虚痰湿型多囊卵巢综合征患者随机分为对照组18例,治疗组22例,对照组采用达英-35治疗,治疗组采用加味苍附导痰汤联合中药包热敷治疗,观察治疗后两组临床疗效、体重指数、血清性激素水平,症状评分,卵巢体积大小及排卵情况的变化。结果:治疗后对照组有效率为83.34%,治疗组有效率为90.9%,治疗组有效率明显高于对照组(P<0.05);治疗前两组血清LH、FSH、T水平均无统计学差异(P>0.05),治疗后对照组仅LH、T水平明显降低(P<0.05),治疗组各血清激素水平均明显降低(P<0.05);治疗前两组腰臀比、BMI均无统计学差异(P>0.05),治疗后对照组腰臀比、BMI反而增高(P<0.05),治疗组腰臀比、BMI明显降低(P<0.05);治疗前两组各症状评分无统计学差异(P>0.05),治疗后患者各症状评分均明显降低(P<0.05),且治疗后治疗组各症状评分均明显低于对照组(P<0.05);两组治疗前卵巢体积及排卵情况差异无统计学意义(P>0.05),治疗后两组卵巢体积明显小于治疗前;且停药后随访3个月观察两组排卵率明显提高(P<0.05),治疗组明显高于对照组(P<0.05)。结论:采用加味苍附导痰汤联合中药包热敷治疗多囊卵巢综合征合可调节激素水平,恢复生殖排卵功能,又可改善代谢情况,且无明显不良反应,值得推广应用。

Objective To evaluate clinical curative effects of modified Cangfu Daotan decoction combined with Chinese herbal bag hot compress in treatment of Kidney Deficiency and Phlegm Stagnation Type of Polycystic Ovary Syndrome （PCOS）. Methods 40 cases of polycystic ovary syndrome were randomly divided into research group （22 cases） and control group （18 cases）. The patients in control group received the treatment of Diane - 35, while those in research group were given modified Cangfu Daotan decoction in ombination with Chinese herbal bag hot compress on the basis of the control. Observe clinical curative effect, body mass index, serum sex hormone levels （FSH, LH, T）, body mass index, waist circumference, hip circumference and symptom scores, ovarian volume size and ovulation of two groups after treatment. Results The research group effective rate was 90. 9% after treatment, control group effective rate was 83. 34%, treatment effectiveness is significantly higher than control group （ P 〈 0. 05 ） ; Two groups of patients before treatment serum LH, FSH, T levels had no significant difference （P 〉 0. 05）, research group after treatment the serum hormone level decreased signifi- cantly （P 〈 0. 05）, the control group only LH, T were significantly reduced （P 〈 0. 05 ） ; Waist - hip ratio and BM1 in both groups before treatment had no significant difference （ P 〉 0. 05 ）, research group after treatment waist - to - hip ratio and BMI significantly reduced （ P 〈 0. 05 ）, control group waist - to - hip ratio, instead of BMI increased （ P 〈 0. 05 ） ; Each symptom scores in both groups before treatment had no significant difference （P 〉 0. 05）, after treatment in patients with the symptom scores were significantly lower （ P 〈 0. 05）, and the patients in research group after treatment the symptom scores were significantly lower than control group （P 〈 0. 05 ） ; In the two groups before treatment in patients with ovarian volume and ovulation difference has no statistical significance （ P 〉 0. 05 ）. In the two groups after treatment of ovarian volume significantly less than before treatment; Followed up for 3 months after the drug was stopped to observe two groups of ovulation rate increased significantly （P 〈 0. 05）, and the research group is significantly higher than control group （P 〈 0. 05）. Conclusion The curative effect of modified Cangfu Daotan decoction combined with Chinese herbal bag hot compress in the treatment of polycystic ovary syndrome patients is no obuious adverse effect and worthy of clinical popularization and application.