血清胱抑素C在评估狼疮肾炎肾功能中的意义

Significance of Serum Cystatin C in Evaluating Renal Function in Lupus Nephritis

目的:探讨血清胱抑素C(cysC)水平在评估狼疮肾炎患者肾功能中的价值。方法:选取皖南医学院弋矶山医院行肾穿刺明确狼疮肾炎的51例患者为LN组,选取健康体检者50例为对照组,收集临床资料。并将LN组分为肾功能正常组及异常组,比较各组间cysC水平的差异。结果:LN组的CysC水平明显高于对照组(P<0.01);肾功能正常组cysC水平高于对照组(P<0.01);肾功能异常组cysC水平较肾功能正常组、健康对照组显著升高(P<0.01)。血清cysC水平评估LN患者早期肾功能损害的敏感度为83%,特异度为61%,ROC曲线下面积为0.716。cysC水平与肾脏病理活动评分呈正相关(r=0.356,P=0.024)。结论:cysC可作为评估LN患者早期肾功能损害的指标之一。

Objective： To investigate the significance of serum cystatin C （CysC） in evaluating renal function in lupus nephritis （LN） . Methods： A total of 51 cases of patients with LN were selected as LN group, 50 cases of healthy people were selected as control group, and patients in the LN group was further divided into normal and abnormal renal fimction groups. The clinical data were collected and the levels of CysC were compared. Results： The levels of CysC in the LN group were significant higher than that in the control group （P〈0.01） . The levels of CysC in the normal renal function group were also higher than the control group. Meanwhile, the levels of CysC in the abnormal renal function group were significantly higher than that in the normal group and in the control group. The sensitivity of CysC in evaluating early renal impairment was 83%, the specificity was 61%, and the area under ROC curve was 0.716. The level of CysC was positively correlated with the renal pathological activity score （r=0.356, P=0.024） . Conclusion： CysC can be used as one of the indexes to evaluate the early renal impairment of patients with LN.