酰基化、非酰基化ghrelin与动脉粥样硬化的关系

Relationships between Acylated and Unacylated Ghrelin and Atherosclerosis

ghrelin是生长激素促分泌物受体的内源性配体,具有多种生物学作用,包括促进生长激素释放、调节摄食和糖脂代谢、保护心血管系统等。体内ghrelin以酰基化和非酰基化两种形式存在,具有各自的生物功能。酰基化和非酰基化ghrelin与动脉粥样硬化及动脉粥样硬化的危险因素之间存在不同的关联,在动脉粥样硬化的发展中起到不同作用。

Ghrelin is a natural endogenous ligand of the growth hormone secretagogue receptor and has various biological functions such as promoting the release of growth hormone, regulation of appetite and metabolism of glucose and lipid, and protective effects on the cardiovascular system. Acylated and unacylated ghrelin are different forms of ghrelin. They have different biological effect respectively. Acylated and unacylated ghrelin have different relationships with atherosclerosis and its related risk factors and play different roles in the development of atherosclerosis.