摘要
中国地鼠在生物医学研究中占有重要的地位,但中国地鼠的分子遗传标记研究尚少。本研究运用生物信息学和比较基因组学等方法分析了中国地鼠的线粒体基因组的碱基组成、基因组结构、基因进化等特征,为中国地鼠应用于人类疾病动物模型提供基因组数据。建立了中国地鼠近交系遗传质量控制体系,为中国地鼠种质资源科学评估、合理开发利用奠定了基础。
Chinese hamster is an important laboratory animal in medical and biological researches,but the molecular genetic markers research was rarely reported.In our study the base composition,gene structure,genetic evolution and other characteristics of mitochondrial genome of Chinese hamster were analyzed using the methods of bioinformatics and comparative genomics,genetic quality detection system of Chinese hamster were also established.These results would supply genome data for animal models of human diseases,and lay the foundation for scientific evaluation and reasonable utilization.
出处
《中国比较医学杂志》
北大核心
2017年第5期4-5,15,共3页
Chinese Journal of Comparative Medicine
基金
山西省实验动物专项资金(2005k01,2009k02)
关键词
中国地鼠
线粒体基因组
分子进化
微卫星
遗传检测
Chinese hamster
Mitochondrial genome
Phylogenetic relationship
microsatellite
Genetic monitoring