急性冠脉综合症患者血清ox-LDL、IL-6R及Hcy水平与不稳定斑块相关性研究

Correlation of Oxidized Low-density Lipoprotein,Interleukin 6 Receptor,and Homocysteine Levels with Unstable Coronary Atherosclerotic Plaque in Patients with Acute Coronary Syndrome(ACS)

目的探讨急性冠脉综合症(ACS)患者外周血清中氧化低密度脂蛋白(ox-LDL)、白细胞介素6受体(IL-6R)及同型半胱氨酸(Hcy)水平对不稳定斑块的预测价值。方法选取经冠状动脉造影检查确诊为冠心病患者208例,其中急性心肌梗死(AMI)90例,不稳定型心绞痛(UAP)87例,稳定型心绞痛(SAP)31例;选取冠状动脉造影证实冠状动脉无狭窄者48例为对照组。采集入院24h内静脉血,ELISA法检测ox-LDL、IL-6R、Hcy水平。结果 ACS患者外周血清中ox-LDL、IL-6R、Hcy水平与对照组相比明显升高,差异有统计学意义(P<0.05);AMI组ox-LDL、IL-6R、Hcy水平显著高于UAP组,差异有统计学意义(P<0.05);UAP组ox-LDL、IL-6R、Hcy水平显著高于SAP组、对照组,差异有统计学意义(P<0.05)。结论联合检测ox-LDL、IL-6R、Hcy有助于对ACS程度的诊断。

Objective To investigate the predictive value of levels of oxidized low-density lipoprotein（ox-LDL）, interleukin-6 receptor（IL-6R）and homocysteine（Hcy）on unstable coronary atherosclerotic plagues in patients with acute coronary syndrome（ACS）. Methods 208 patients with coronary heart disease confirmed by coronary angiog- raphy were selected,including 90 cases of acute myocardial infraction（AMI）, 87 cases of unstable angina patients （UAP） and 31 cases of stable angina patients（SAP）. 48 patients without coronary artery stenosis confirmed by cor- onary angiography were selected into control group. In the vein blood collected within 24 hours of admission, the level of ox-LDL, IL-6R and Hcy were determined by ELESA. Results The serum levels of ox-LDL, IL-6R and Hcy in the group of acute myocardial infraction were significantly higher than those of control group（P〈0.05）. The serum levels of ox-LDL, IL-6R and Hcy in the group of myocardial infraction were significantly higher than those in unstable angina group（P〈0. 05）. The serum levels of ox-LDL,IL-6R arid Hcy in the group of unstable angina were significantly higher than those in stable angina group（P〈0.05）. Conclusion Combined detection may be of help to early clinical diagnosis of acute coronary svndrome（ACS）.