干扰素-γ诱导蛋白10在子痫前期孕妇血清和胎盘组织中的表达及意义

Expression and significance of interferon-γ inducible protein 10 in serum and placenta of pregnant women with preeclampsia

目的探讨干扰素-γ诱导蛋白10(IP-10)在子痫前期(PE)孕妇血清和胎盘组织中的表达及意义。方法选择2015年1月~2017年2月61例PE孕妇,按照严重程度分为轻度PE组(33例)与重度PE组(28例);按照发病时间分为早发型PE组(24例)与晚发型PE组(37例),同期30例正常妊娠者为正常对照组,比较组间血清和胎盘组织中IP-10的表达情况。结果与正常对照组比较,轻度与重度PE组孕妇的血清IP-10水平、胎盘组织IP-10蛋白表达量均明显升高(P均<0.05),且重度PE组均明显高于轻度PE组(P均<0.05),但早发型与晚发型PE组之间比较均无明显差异(P均>0.05)。结论 PE孕妇血清和胎盘组织中IP-10的表达过度,可能通过介导炎症反应及抑制血管新生参与疾病的发生。

Objective To investigate the expression and significance of interferon-γ inducible protein 10 in serum and placenta of pregnant women with preeclampsia. Methods 61 pregnant women with PE from Jan.2015 to Feb. 2017 were selected according to the severity, the patients were divided into mild PE group（33 cases） and severe PE group（n=28）. According to the time of onset, the patients were divided into early onset PE group（n=24） and late onset PE group（n=37）, and the normal control group was normal pregnancy with 30 cases. The expression of IP-10 in serum and placenta tissue was compared between groups. Results Compared with the normal control group, the levels of IP-10 in serum and placenta of the mild and severe PE group were significantly higher（P〈0.05） ,and of the severe PE group were significantly higher than those of the mild PE group（P〈0.05）,while there were no significant difference between early onset and late onset PE group（P〉0.05）. Conclusion IP-10 in serum and placenta of pregnant women with PE are Overexpressed, which may be involved in the occurrence of disease by mediating inflammation and inhibiting angiogenesis.