同型半胱氨酸在老年2型糖尿病合并脑梗死患者中的诊断价值

Diagnostic value of homocysteine in elderly patients with type 2 diabetes mellitus complicated with cerebral iInfarction

目的探讨同型半胱氨酸在老年2型糖尿病合并脑梗死患者中的诊断价值。方法采用回顾性分析,选取我院在2016年6~12月期间收治的122例老年2型糖尿病住院患者,按照随机原则,将患者分为两组,单纯糖尿病组(78例),合并脑梗死组(44例),测定两组患者身高、体重,抽空腹血检查血清同型半胱氨酸、糖化血红蛋白HbA1c、空腹静脉血糖及空腹胰岛素。结果两组患者BMI(体重指数)、血同型半胱氨酸、HOMA-IR相比,差异具有统计学意义(P<0.05);两组间糖化血红蛋白HbA1c、空腹静脉血糖、空腹胰岛素无显著性差异(P>0.05);Logistic回归分析结果显示,同型半胱氨酸与HOMA-IR呈显著正相关(P<0.05)。结论高同型半胱氨酸血症是老年2型糖尿病合并脑梗死的危险因素,并且胰岛素抵抗与血清同型半胱氨酸水平具有相关性。

Objective To investigate the diagnostic value of homocysteine in elderly patients with type 2 diabetes mellitus complicated with cerebral infarction. Methods Retrospective analysis was performed to select 122 hospitalized elderly patients with type 2 diabetes mellitus who were admitted to our hospital from June to December 2016. According to the principle of randomization, the patients were divided into two groups, namely diabetic group （78 cases）, and combined cerebral infarction group（44 cases）. The height, body weight, levels of serum homocysteine by fasting blood sampling, glycosylated hemoglobin HbAlc, fasting venous blood glucose and fasting insulin were detected in both groups. Results The differences of BMI（body mass index）, blood homocysteine and HOMA-IR compared between the two groups were statistically significant（P〈0.05） there was no significant difference in glycosylated protein hemoglobin HbAlc, fasting venous blood glucose and fasting insulin between the two groups（P〉0.05）; Logistic regression analysis showed that homocysteine had a significant positive correlation with HOMA-IR（P〈0.05）. Conclusion Hyperhomocysteinemia is a risk factor for elderly patients with type 2 diabetes mellitus complicated with cerebral infarction, and insulin resistance is correlated with serum homocysteine levels.