急性脑梗死患者合并高尿酸血症对其预后的影响研究

Effect of hyperuricemia on prognosis in patients with acute cerebral infarction

目的:探讨高尿酸血症对急性脑梗死患者预后的影响,为早期预防和改善其预后提供依据。方法:将确诊的184例急性脑梗死患者,依据是否合并高尿酸血症分为正常组(128例)和高尿酸组(56例),采用NIHSS量表、NDS量表及改良Rankin量表来评估患者的病情严重程度和预后情况,比较2组患者治疗后的NIHSS评分、总有效率及预后不良率。结果:治疗后,2组患者的NIHSS评分均有所改善,但高尿酸组的NIHSS评分仍然明显高于正常组(P<0.05);高尿酸组的治疗总有效率为73.2%,明显低于正常组的93.8%(P<0.05);高尿酸组的预后不良率为32.1%,明显高于正常组的9.4%(P<0.05)。结论:高尿酸血症是急性脑梗死的独立危险因素,在急性脑梗死的发生、发展和预后过程中起到重要的作用。

[Objective] To investigate the effect of hyperuricemia on the prognosis of patients with acute cerebral infarction and provide the basis for early prevention and improvement of prognosis. [Method] A total of 184 patients with acute cerebral in- farction were divided into normal group （ 128 cases） and hyperuficemia group （56 cases） according to whether or not hyper- uricemia was combined. NIHSS scale, NDS scale and modified Rankin scale were used to assess the severity and prognosis of the patients. The NIHSS score, total effective rate and poor prognosis were compared between the two groups. [Result] The NIHSS scores of the two groups were improved after treatment, but the NIHSS score of the hyperuricemia group was still signif- icantly higher than that of the normal group （ P 〈 0.05）. The total effective rate was 73.2% in the treatment group, which was significantly lower than that in the normal group （93.8 %, P 〈 0.05）. The poor prognosis rate of the hyperuric acid group was 32.1%, which was significantly higher than that of the normal group （9.4%, P 〈 0.05）. [ Conclusion] Hyperuricemia is an independent risk factor for acute cerebral infarction and plays an important role in the development, progression and prognosis of acute cerebral infarction.