果糖二磷酸钠联合维生素C治疗新生儿窒息后心肌损害的疗效观察

Efficacy of Fructose Sodium Diphosphate Combined With Vitamin C in the Treatment of Neonatal Asphyxia

目的探究新生儿患者窒息后心肌损害使用果糖二磷酸钠联合维生素C治疗后的临床效果。方法选择我院儿科收治的新生儿窒息后心肌损害患者196例,依据治疗方法的不同将患者平均分为观察组与对照组各98例,对照组采用常规治疗,观察组在对照组的基础上给予果糖二磷酸钠联合维生素C治疗,对比两组患者治疗后的临床效果。结果分析两组患者治疗后血清肌酸激酶、心肌肌钙蛋白I以及肌酸激酶同工酶,观察组低于对照组,每组指标对比差异都有统计学意义,P<0.05;比较两组患者治疗有效率,对照组为70.4%,观察组为92.8%,对比差异有统计学意义,P<0.05;对比两组患者的患者满意度,对照组为63.2%,观察组为95.9%,对比差异有统计学意义,P<0.05。结论新生儿患者窒息后心肌损害使用果糖二磷酸钠联合大剂量维生素C治疗,可以有效增加临床治疗有效率,减少不良反应的发生,提高患者满意度。

Objective To investigate the clinical effect of fructose sodium phosphate and vitamin C in the treatment of neonatal myocardial damage after asphyxia. Methods To choose our hospital pediatric treated 196 patients with myocardial injury after neonatal asphyxia, according to the different method of treatment to patients, on average, were divided into observation group and the control group （n = 98）, and the control group using conventional treatment, on the basis of control group, observation group given fructose sodium phosphate combined vitamin C treatment, compared the clinical effect of two groups of patients after treatment. Results The serum creatine kinase, cardiac troponin I and CK isoenzyme were analyzed in the two groups after treatment. The observation group was lower than that of the control group, the difference of each index was statistically significant, P 〈 0.05. Compared with the two groups, the effective rate of treatment was 70.4% in the control group and 92.8% in the observation group, the difference was statistically significant, P 〈 0.05. The satisfaction of the patients in the control group was 63.2% compared with that in the observation group （95.9%）. The difference between the two groups was statistically significant, P 〈 0.05. Conclusion The use of fructose two phosphate sodium combined with large dose of vitamin C can effectively increase the efficiency of clinical treatment, reduce the incidence of adverse reactions and improve the satisfaction of patients.