正常及妊娠高血压综合征孕妇凝血功能检测的意义探讨

Significance of Blood Coagulation Detection in Normal Pregnant and Women With Pregnancy Induced Hypertension

目的探讨妊娠高血压综合征(妊高征)孕妇凝血功能指标的变化。方法选择249例妊高征孕妇为观察组,另选取同时期249名正常孕妇(正常组)和249名非孕妇(非孕组)作为对照,分别检测其活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)、纤维蛋白原(FIB)、D2聚体指标,并进行组间对照分析。结果观察组与正常组孕妇APTT、PT均较非孕组缩短,FIB、D2聚体水平较非孕组升高,且观察组的变化更加明显,差异均具有统计学意义(P<0.05)。结论孕妇多项凝血功能指标可发生明显变化,妊高征孕妇凝血功能指标变化更为显著,提示孕妇产前做好凝血功能检测意义重大。

Objective To explore the changes of blood coagulation detection in normal pregnant and women with pregnancy induced hypertension. Methods 249 cases with induced hypertension in our hospital were selected as observation group. In the same period, 249 normal, pregnant women （normal group） and 249 non-pregnancy women （non-pregnancy group） were selected and served as control. The APTT, PT, FIB and D2 （dimer index） were detected and compared. Results In observation group and normal group, APTT and PT index were shorter than non-pregnancy group and the FIB level and D2 dimer index was higher than non-pregnancy group. The changes ofAPTT, PT and FIB index in observation group were more obvious than the other two groups （P〈0.05）. Conclusion The blood coagulation was changed in pregnancy and showed a significant variation in women with pregnancy induced hypertension. Blood coagulation detection has important significance.