细胞学联合病原微生物检测筛查宫颈癌的临床应用分析

Cytology Combined Analysis of the Clinical Application of Pathogenic Microorganisms Screening Cervical Cancer

目的探究细胞学联合病原微生物检测筛查宫颈癌的临床价值情况。方法选择2015年9月—2016年9月我院收治的宫颈病变者1 104例作为研究对象。利用液基标本制作宝薄片细胞学诊断与HPV,HSV-II,UU,CT的DNA检测。细胞学诊断利用TBS分级系统进行,阳性诊断结果包含ASCUS以上病变,诊断结果为阳性者使用阴道镜活检进行对照。结果本次实验中,LSIL为90例,HSIL为140例,SCC为10例,细胞学诊断在LSIL以上者的人数比例为140/1 104,占总数的12.68%,阴道镜活检的阳性人数比例为276/1 104,占总数的25.00%。组间对比,差异不具有统计学意义(P>0.05)。184例HPV感染者的细胞学检验结果高于ASCUS,占病理活检阳性概率的66.67%(184/276)。结论使用宫颈液基细胞收集法,可做到单次取材。进而做到细胞学与病原微生物的全面检查,液基细胞学联合病原微生物检测,可在最大程度上提升宫颈癌与癌前病变检出率,为宫颈筛查工作的重要工具,HPV为发生宫颈癌和癌前病变的主要性因素,病原菌感染可能对癌变过程起到辅助作用。

Objective To explore the cytological joint pathogenic microorganism testing the clinical value of screening for cervical cancer. Methods From September 21115 to September 2016 in our hospital, 1 104 cases as the research object of cervical lesions. Using liquid, a taxidermist chip cytological diagnosis and HPV HSV-Ⅱ, UU, CT DNA testing. Cytological diagnosis of TBS classification system, the diagnosis for colposcopy biopsy was used for comparison. Results In this experiment, LSIL lbr 90 cases, HSIL for 140 example, SCC for 10 example, cytological diagnosis in LSIL above proportion lbr 140/1 104, 12.68% of the total, colposcopy biopsy positive proportion for 276/1 104, 25.00% of the total, there was no statistical difference between two groups （P 〉 0.05）. 184 cxamplc HPV infection of cytology test results on the ASCUS paper, accounting for 66.67% of the pathologic biopsy positive probability （184/276）. Conclusion Cervical liquid collecting cells, can do a single drawing. And from the comprehensive review of cytology and pathogenic microorganism liquid based cytology combined pathogenic microorganism inspection, can promote cervical cancer and precancerous lesions in the largest degree detection rate, important tools work lbr cervical screening, HPV for cervical canccr and precancerous lesions of the main factors, pathogen infection may play a supplementary rote ofcanceration process.