胃癌患者血清中肿瘤标志物检测对于化疗疗效评估的意义研究

Clinical Significance of Serum Tumor Markers in Patients With Gastric Cancer

目的研究检测胃癌患者血清中肿瘤标志物的表达水平对于化疗疗效评估的意义。方法以本院2014年6月—2016年6月收治的56例胃癌患者作为研究对象,全部患者均于本院接受化疗3周期,分别于化疗前、后检测患者血清中的肿瘤标志物表达水平,以胃镜检查作为化疗疗效评估的金标准,计算血清肿瘤标志物评估化疗疗效的诊断价值,分析与金标准的差异性。结果肿瘤标志物CEA对化疗疗效的评估结果与金标准比较,差异有统计学意义,P<0.05;CA724、CA199及三项联合评估与金标准比较,差异均无统计学意义,P>0.05;三项联合评估诊断的符合率为75.00%,敏感性为70.37%,特异性为79.31%。结论以胃癌化疗患者血清中肿瘤标志物的表达水平,评估化疗疗效具有较高的诊断符合率、特异性与敏感性,对于化疗疗效的评估具有数字化的参考意义。

Objective To study the value of expression level of tumor markers in serum of patients with gastric cancerforassessment ofthe efficacy of chemotherapy. Methods 56 cases of patients with gastric cancer in our hospital from June 2014 to June 2016 were taken as the object of study, they were administrated chemotherapy for three cycles, the level of serum tumor marker was determined before and afterchemotherapy. Gastroscope inspection was regarded asthe gold standard to efficacy evaluation of chemotherapy, the diagnostic value ofserum tumor marker was calculated and compared with the gold standard. Results There was significant statistics difference between the tumor marker CEA and the gold standard with regard to the evaluation of the chemotherapy efficacy, P〈0.05, there were no significant statistics differences among CA724, CA199, and the three combinationassessment and the gold standard, P〉0.05, diagnostic coincidence rate of three combination assessment was 75.00%, the sensitivity was 70.37%, the specificity was 79.31%. Conclusion The evaluation of chemotherapy efficacyby the expression serumlevel of tumor markers in gastric cancer patients, has high diagnostic coincidence rate, specificity and sensitivity, and has a digital reference value for the evaluation of chemotherapy efficacy