多巴酚丁胺联合硝酸甘油治疗妊娠合并心力衰竭的临床效果

Clinical Effect of Dobutamine Combined With Nitroglycerin in the Treatment of Pregnancy Complicated With Heart Failure

目的探究与分析多巴酚丁胺联合硝酸甘油对妊娠合并心力衰竭的治疗疗效。方法选取我院2014年9月—2016年9月我院收治的妊娠合并心力衰竭患者156例作为研究对象。采用随机数字表,将其分为试验组和对照组,对照组患者采用硝酸甘油进行治疗,试验组患者采用多巴酚丁胺联合硝酸甘油进行治疗,记录并观察两组患者治疗前后BNP水平变化和发生头疼、恶心、腹泻不良反应的情况,并统计治疗的总有效率。结果试验组患者BNP水平低于对照组,差异具有统计学意义(P<0.05)。两组患者均有发生头疼、恶心和腹泻的不良反应情况,组间对比,差异无统计学意义(P>0.05)。试验组总有效率为69.23%,对照组总有效率为38.46%,试验组总有效率高于对照组,差异具有统计学意义(P<0.05)。结论多巴酚丁胺联合硝酸甘油治疗妊娠合并心力衰竭,可明显降低BNP水平,提高治疗总有效率。

Objective To explore the therapeutic effect of the dopamine nitroglycerine in pregnancy combined with heart failure. Methods From September 2014 to September 2016, 156 cases of pregnancy with heart failure patients in ottr hospital were selected as the study object. According to the random number table, which were divided into experimental group and control group. Patients in the control group were treated with nitroglycerin. The patients in the experimental group were treated with dobutamine combined with nitroglycerin. The changes of BNP levels and adverse reactions of headache, nausea and diarrhea were recorded and observed before and after treatment in two groups, the total effective rate of the treatment was also counted. Results Compared with the control group, the BNP level was significantly decreased compared with the control group, and the difference was statistically significant （P〈0.05）. Both groups had adverse reactions to headaches, nausea and diarrhoea, the difference was not statistically significant （P〉0.05）. The total efficiency of the test group was 69.23%, and the control group＇s total efficiency was 38.46%, the total efficiency of the test group was significantly higher than the control group （P〈0.05）. Conclusion Dobutamine combined nitroglycerin treatment of pregnancy with heart failure, can obviously reduce the BNP level, improve the total effective rate of treatment.